The effect of CA1 dopaminergic system in harmaline-induced amnesia

Highlights • Pre-training intra-CA1 infusion of dopamine D1 and D2 receptor drugs induce amnesia. • I.p. administration of harmaline impaired memory acquisition. • SCH23390 and sulpiride reverse amnesia induced by harmaline. • SKF38393 and quinpirole potentiate amnesia induced by harmaline. • Co-inj...

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Bibliographic Details
Published in:Neuroscience 2015-01, Vol.285, p.47-59
Main Authors: Nasehi, M, Ketabchi, M, Khakpai, F, Zarrindast, M.-R
Format: Article
Language:English
Subjects:
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology
Amnesia - chemically induced
Amnesia - drug therapy
Amnesia - metabolism
Animals
Avoidance Learning - drug effects
Avoidance Learning - physiology
Benzazepines - pharmacology
CA1
CA1 Region, Hippocampal - drug effects
CA1 Region, Hippocampal - metabolism
dopamine
Dopamine - metabolism
Dopamine Agonists - pharmacology
Dopamine Antagonists - pharmacology
harmaline
Harmaline - toxicity
Male
Memory - drug effects
Memory - physiology
Mice
Monoamine Oxidase Inhibitors - toxicity
Neurology
passive avoidance memory
Receptors, Dopamine D1 - metabolism
Receptors, Dopamine D2 - metabolism
step-down
Sulpiride - pharmacology
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Summary:Highlights • Pre-training intra-CA1 infusion of dopamine D1 and D2 receptor drugs induce amnesia. • I.p. administration of harmaline impaired memory acquisition. • SCH23390 and sulpiride reverse amnesia induced by harmaline. • SKF38393 and quinpirole potentiate amnesia induced by harmaline. • Co-injection of SKF/sulpiride or SCH23390/sulpiride rise amnesia caused by harmaline.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.11.012