Synthesis and Antimicrobial Activity Evaluation of Novel Oxadiazino/Thiadiazino-Indole and Oxadiazole/Thiadiazole Derivatives of 2-Oxo-2H-benzopyran

A series of novel oxadiazino/thiadiazino‐indole and oxadiazole/thiadiazole derivatives of 2‐oxo‐2H‐benzopyran were synthesized and evaluated for their antimicrobial activities against the bacteria Staphylococcus aureus, Salmonella typhi, and Escherichia coli and two fungal species Candida albicans a...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2014-05, Vol.51 (3), p.719-725
Main Authors: Deokar, H., Chaskar, J., Chaskar, A.
Format: Article
Language:English
Subjects:
Antimicrobial agents
Aspergillus niger
Candida albicans
Escherichia coli
Medical research
Salmonella typhi
Staphylococcus aureus
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Summary:A series of novel oxadiazino/thiadiazino‐indole and oxadiazole/thiadiazole derivatives of 2‐oxo‐2H‐benzopyran were synthesized and evaluated for their antimicrobial activities against the bacteria Staphylococcus aureus, Salmonella typhi, and Escherichia coli and two fungal species Candida albicans and Aspergillus niger. The antibacterial activities were expressed as minimum inhibitory concentration (MIC50) in microgram per milliliter. The title compounds 4b and 10b revealed promising antibacterial activity whereas 6d, 7d, 9d, and 10b exhibited significantly impressive antifungal activity.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.1761