Regulatory T cells in systemic lupus erythematosus

Systemic lupus erythematosus (SLE), an autoimmune disease, develops when immunologic self‐tolerance fails. Treg cells are a subset of CD4+ T cells that maintain self‐tolerance by suppressing autoreactive lymphocytes. Defects in Treg cells are therefore considered to be an aspect of SLE pathogenesis....

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Bibliographic Details
Published in:European journal of immunology 2015-02, Vol.45 (2), p.344-355
Main Authors: Ohl, Kim, Tenbrock, Klaus
Format: Article
Language:English
Subjects:
Animals
Autoimmune diseases
Autoimmunity
Biomarkers - metabolism
Disease Models, Animal
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - immunology
FoxP3
Gene Expression
Helios
Humans
Ikaros Transcription Factor - genetics
Ikaros Transcription Factor - immunology
Immune system
Immune Tolerance
Immunotherapy - methods
Lupus
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - pathology
Lupus Erythematosus, Systemic - therapy
Lymphocyte Activation
Lymphocytes
Mice
Regulatory T‐cell subsets
Systemic lupus erythematosus
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - pathology
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Summary:Systemic lupus erythematosus (SLE), an autoimmune disease, develops when immunologic self‐tolerance fails. Treg cells are a subset of CD4+ T cells that maintain self‐tolerance by suppressing autoreactive lymphocytes. Defects in Treg cells are therefore considered to be an aspect of SLE pathogenesis. Nevertheless, reports on the numbers and function of Treg cells in SLE are contradictory and the definitive role of Treg cells in SLE remains unclear. In this review, we summarize findings from murine models and ex vivo experiments, which provide insights into the mechanisms that result in the breakdown of tolerance. We also include recent findings about Treg‐cell subsets and their markers in human SLE. The identification of unique markers to identify bona fide Treg cells, as well as therapies to reconstitute the balance between Treg cells and autoreactive T cells in SLE, are the future challenges for SLE research.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201344280