High-resolution MR imaging of the arterial wall in moyamoya disease

•Different types of middle cerebral artery stenosis are identified by HRMRI.•The differences between MMD and intracranial atherosclerotic stenosis are elucidated by HRMRI.•Outer diameter and wall thickness of the MCAs in different MRA stages are compared.•The possible mechanism of arterial progressi...

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Bibliographic Details
Published in:Neuroscience letters 2015-01, Vol.584, p.77-82
Main Authors: Yuan, Min, Liu, Zhi-qiang, Wang, Zhi-qiang, Li, Bin, Xu, Li-jun, Xiao, Xin-lan
Format: Article
Language:English
Subjects:
Adult
Aged
Arterial wall
Atherosclerosis
Atherosclerosis - pathology
Carotid Stenosis - pathology
Case-Control Studies
Female
HRMRI
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Middle Cerebral Artery - pathology
Moyamoya disease
Moyamoya Disease - pathology
Prospective Studies
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Summary:•Different types of middle cerebral artery stenosis are identified by HRMRI.•The differences between MMD and intracranial atherosclerotic stenosis are elucidated by HRMRI.•Outer diameter and wall thickness of the MCAs in different MRA stages are compared.•The possible mechanism of arterial progressive stenosis in MMD is analyzed. High resolution magnetic resonance imaging (HRMRI) has been developed as an emerging tool for evaluating intracranial arterial disease. We aimed to analyze the progression of diseased arterial walls in moyamoya disease (MMD) and further elucidate differences compared to intracranial atherosclerotic stenosis using HRMRI. The population of this HRMRI study consisted of 21 patients with MMD and 44 patients with atherosclerotic middle cerebral artery (MCA) stenosis. The cross-sectional images of the MCA wall on HRMRI were compared between the two groups based on outer diameter, wall thickness, luminal stenotic morphology, signal intensity, collateral vascular structures adjacent to stenotic position. In addition, stage classification based on MRA finding was used to depict the course of moyamoya disease. We compared outer diameter and wall thickness of the MCAs in different MRA stages. As a result, the outer diameter and wall thickness of MCAs were significantly smaller in the MMD group than in the atherosclerosis group (outer diameter: MMD 2.01±0.31mm vs. atherosclerosis 3.31±0.37mm, p
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2014.10.021