Carotid body removal for treatment of chronic systolic heart failure

Abstract Background Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome. Methods and results We present a case of a 56-year-old male patient with ischaemic CHF, who u...

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Bibliographic Details
Published in:International journal of cardiology 2013-10, Vol.168 (3), p.2506-2509
Main Authors: Niewiński, Piotr, Janczak, Dariusz, Rucinski, Artur, Jazwiec, Przemyslaw, Sobotka, Paul A, Engelman, Zoar J, Fudim, Marat, Tubek, Stanislaw, Jankowska, Ewa A, Banasiak, Waldemar, Hart, Emma C.J, Paton, Julian F.R, Ponikowski, Piotr
Format: Article
Language:English
Subjects:
Autonomic imbalance
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular
Carotid Body - surgery
Carotid body chemoreceptors
Chronic Disease
Heart
Heart failure
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Heart Failure, Systolic - surgery
Humans
Male
Medical sciences
Middle Aged
Surgical resection
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Summary:Abstract Background Augmented reflex response from peripheral chemoreceptors characterises chronic heart failure (CHF), contributes to autonomic imbalance and exercise intolerance and predicts poor outcome. Methods and results We present a case of a 56-year-old male patient with ischaemic CHF, who underwent surgical, unilateral carotid body resection to reduce peripheral chemosensitivity. At 2-month and 6-month follow-ups, we document a persistent decrease in peripheral chemosensitivity accompanied by an improvement in exercise capacity, sleep disordered breathing and quality of life. Autonomic balance was favourably affected as evidenced by improved heart rate variability and augmented cardiac baroreflex sensitivity. There were no procedure-related adverse events. Conclusions Denervation of a carotid body may offer a clinical strategy to restore autonomic balance and improve morbidity in heart failure ( NCT01653821 ).
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2013.03.011