Vaccine protection of chickens against antigenically diverse H5 highly pathogenic avian influenza isolates with a live HVT vector vaccine expressing the influenza hemagglutinin gene derived from a clade 2.2 avian influenza virus

Highlights • A recombinant HVT vaccine expressing a H5 HA gene provided homologous and heterologous protection. • Antibodies exhibited high levels of reaction against homologous but not heterologous H5 virus. • Lymphocytes from vaccinated chickens recognized target cells infected with H5, H6, H7, or...

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Bibliographic Details
Published in:Vaccine 2015-02, Vol.33 (9), p.1197-1205
Main Authors: Kapczynski, Darrell R, Esaki, Motoyuki, Dorsey, Kristi M, Jiang, Haijun, Jackwood, Mark, Moraes, Mauro, Gardin, Yannick
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal vaccines
Animals
Antibodies
Antigens
Avian influenza virus
Birds
Cellular immunity
Chickens
Cytotoxicity
Cytotoxicity Tests, Immunologic
Drug Carriers
Experiments
Genetic Vectors
Hemagglutinin Glycoproteins, Influenza Virus - genetics
Hemagglutinin Glycoproteins, Influenza Virus - immunology
Herpesvirus 1, Meleagrid - genetics
Highly pathogenic avian influenza
Immunity, Heterologous
Influenza A Virus, H5N1 Subtype - immunology
Influenza A Virus, H5N2 Subtype - immunology
Influenza in Birds - immunology
Influenza in Birds - pathology
Influenza in Birds - prevention & control
Influenza in Birds - virology
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Laboratories
Lymphocytes
Peptides
Poultry
Studies
Survival Analysis
Turkey herpesvirus
Vaccines
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - immunology
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - immunology
Vector-based vaccine
Virus Shedding
Viruses
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Description
Summary:Highlights • A recombinant HVT vaccine expressing a H5 HA gene provided homologous and heterologous protection. • Antibodies exhibited high levels of reaction against homologous but not heterologous H5 virus. • Lymphocytes from vaccinated chickens recognized target cells infected with H5, H6, H7, or H9 AI. • Live recombinant vaccines induce humoral and cellular immunity which contribute to protection.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.12.028