Synthesis of Au yolk/LDH shell nanoparticles as anticancer vehicles

In this paper, anticancer drug methotrexate (MTX) is applied as a coupling agent to fabricate Au[at]SiO sub(2) core-shell structures for the first time. Then, a novel kind of Au yolk/LDH shell nanoparticles is obtained by using Au[at]SiO sub(2) as the template. Finally, the in vitrocytotoxicity is e...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (12), p.8689-8692
Main Authors: Huo, Xiaolei, Dai, Chaofan, Li, Shuping, Li, Xiaodong
Format: Article
Language:English
Subjects:
Anticancer properties
Coupling agents
Drugs
Effectiveness
Gold
Nanoparticles
Nanostructure
Shells
Vehicles
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Summary:In this paper, anticancer drug methotrexate (MTX) is applied as a coupling agent to fabricate Au[at]SiO sub(2) core-shell structures for the first time. Then, a novel kind of Au yolk/LDH shell nanoparticles is obtained by using Au[at]SiO sub(2) as the template. Finally, the in vitrocytotoxicity is examined and the result indicates that the yolk/shell nanovehicles loaded with MTX exhibit superior anticancer efficacy, compared to the free drug.
ISSN:2046-2069
2046-2069
DOI:10.1039/c4ra14585b