The design trend in tissue-engineering scaffolds based on nanomechanical properties of individual electrospun nanofibers

This paper especially highlights the finding that the mechanical properties of polymeric nanofibers can be tuned by changing the fiber size as well as the composition. For this purpose, the bending Young's modulus was determined using atomic force microscope by involving single-material (polyvi...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 2013-10, Vol.455 (1-2), p.338-347
Main Authors: Janković, Biljana, Pelipenko, Jan, Škarabot, Miha, Muševič, Igor, Kristl, Julijana
Format: Article
Language:English
Subjects:
Atomic force microscopy
Calorimetry, Differential Scanning
cartilage
chitosan
Chitosan - chemistry
Elastic Modulus
Elasticity
Electrospinning
engineering
Hot Temperature
hyaluronic acid
Hyaluronic Acid - chemistry
mechanical properties
Microscopy, Atomic Force
modulus of elasticity
Nanofiber
nanofibers
Nanofibers - chemistry
polyethylene glycol
Polyethylene Glycols - chemistry
polyvinyl alcohol
Polyvinyl Alcohol - chemistry
Tissue engineering
Tissue Engineering - methods
tissue scaffolds
Tissue Scaffolds - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This paper especially highlights the finding that the mechanical properties of polymeric nanofibers can be tuned by changing the fiber size as well as the composition. For this purpose, the bending Young's modulus was determined using atomic force microscope by involving single-material (polyvinyl alcohol (PVA), polyethylene oxide (PEO 400K)) and composite nanofibers (polyvinyl alcohol/hyaluronic acid (PVA/HA), polyethylene oxide/chitosan (PEO 400K/CS)). The mechanical property, namely the bending Young's modulus, increases as the diameter of the fibers decreases from the bulk down to the nanometer regime (less than 200nm). The ranking of increasing stiffness according to the AFM measurements of the three-point beam bending test are in agreement, and can be ranked: PEO 400K
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2013.06.083