Toxicity of thallium on isolated rat liver mitochondria: The role of oxidative stress and MPT pore opening

Thallium(I) is a highly toxic heavy metal; however, up to now, its mechanisms are poorly understood. The authors' previous studies showed that this compound could induce reactive oxygen species (ROS) formation, reduced glutathione (GSH) oxidation, membrane lipid peroxidation, and mitochondrial...

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Bibliographic Details
Published in:Environmental toxicology 2015-02, Vol.30 (2), p.232-241
Main Authors: Eskandari, M R, Mashayekhi, Vida, Aslani, Majid, Hosseini, Mir‐Jamal
Format: Article
Language:English
Subjects:
adenosine triphosphate
Adenosine Triphosphate - metabolism
Animals
cell death
cytochrome c
Cytochromes c - metabolism
glutathione
Glutathione - metabolism
heavy metals
hepatotoxicity
Hydrogen Peroxide - metabolism
isolated mitochondria
lipid peroxidation
Lipid Peroxidation - drug effects
liver
Male
Malondialdehyde - metabolism
membrane potential
Membrane Potential, Mitochondrial - drug effects
mitochondria
Mitochondria, Liver - drug effects
mitochondrial membrane
Mitochondrial Membrane Transport Proteins - drug effects
mitochondrial permeability transition
Mitochondrial Swelling - drug effects
oxidation
oxidative stress
Oxidative Stress - drug effects
Permeability
Rats
Rats, Sprague-Dawley
reactive oxygen species
Reactive Oxygen Species - metabolism
thallium
Thallium - toxicity
thallium(I)
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Summary:Thallium(I) is a highly toxic heavy metal; however, up to now, its mechanisms are poorly understood. The authors' previous studies showed that this compound could induce reactive oxygen species (ROS) formation, reduced glutathione (GSH) oxidation, membrane lipid peroxidation, and mitochondrial membrane potential (MMP) collapse in isolated rat hepatocyte. Because the liver is the storage site of thallium, it seems that the liver mitochondria are one of the important targets for hepatotoxicity. In this investigation, the effects of thallium on mitochondria were studied to investigate its mechanisms of toxicity. Mitochondria were isolated from rat liver and incubated with different concentrations of thallium (25–200 µM). Thallium(I)‐treated mitochondria showed a marked elevation in oxidative stress parameters accompanied by MMP collapse when compared with the control group. These results showed that different concentrations of thallium (25–200 µM) induced a significant (P 
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.21900