Protective effects of caffeic acid phenethyl ester on the dose‐dependent acute nephrotoxicity with paraquat in a rat model

Paraquat (PQ), which is used extensively as a potent herbicide throughout the world, is highly toxic in humans. We aimed to determine PQ‐induced biochemical and histologic changes in the kidneys, and to evaluate the ability of the protective effects of caffeic acid phenethyl ester (CAPE) against PQ‐...

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Bibliographic Details
Published in:Environmental toxicology 2015-03, Vol.30 (3), p.375-381
Main Authors: Rifaioglu, Murat Mehmet, Sefil, Fatih, Gokce, Hasan, Nacar, Ahmet, Dorum, Bayram Ali, Davarci, Mursel
Format: Article
Language:English
Subjects:
acute effects
animal models
Animals
antioxidants
Antioxidants - metabolism
Antioxidants - pharmacology
caffeic acid
caffeic acid phenethyl ester
Caffeic Acids - pharmacology
CAPE
dose response
Female
Herbicides - toxicity
Humans
kidney
Kidney - pathology
Kidney Diseases - chemically induced
Kidney Diseases - pathology
Kidney Diseases - prevention & control
kidneys
nephrotoxicity
oxidants
Oxidation-Reduction
paraquat
Paraquat - antagonists & inhibitors
Paraquat - toxicity
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacology
protective effect
rat
Rats
Rats, Wistar
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Summary:Paraquat (PQ), which is used extensively as a potent herbicide throughout the world, is highly toxic in humans. We aimed to determine PQ‐induced biochemical and histologic changes in the kidneys, and to evaluate the ability of the protective effects of caffeic acid phenethyl ester (CAPE) against PQ‐induced injury in rats. Forty‐eight rats were divided into eight groups of six: Group 1: Control; Group 2: 10 μmol/kg CAPE; Group 3: 15 mg/kg PQ; Group 4: 30 mg/kg PQ; Group 5: 45 mg/kg PQ; Group 6: 15 mg/kg PQ+CAPE; Group 7: 30 mg/kg PQ+CAPE; Group 8: 45 mg/kg PQ+CAPE. PQ and CAPE were injected intraperitoneally. The levels of the total oxidant status (TOS) and total antioxidant status (TAS) were determined in the supernatants of the excised left kidney. Right kidney tissue of each rat was removed to obtain a histologic score. When PQ‐administrated (15, 30, 45) groups compared with other groups, TOS values were found to be significantly higher (p 
ISSN:1520-4081
1522-7278
DOI:10.1002/tox.21915