Effect of hypertension on the resting-state functional connectivity in patients with Alzheimer's disease (AD)

Highlights • We compared resting-state functional connectivity in AD with vs. without hypertension. • We observed reduced connectivity between ACC and PCC in hypertension group. • Our results suggest that hypertension may cause further pathologies in AD brains.

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Bibliographic Details
Published in:Archives of gerontology and geriatrics 2015-01, Vol.60 (1), p.210-216
Main Authors: Son, Sang Joon, Kim, Jinna, Lee, Eun, Park, Jin Young, Namkoong, Kee, Hong, Chang Hyung, Ku, Jeonghun, Kim, Eosu, Oh, Byoung Hoon
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - physiopathology
Alzheimer Disease - psychology
Alzheimer's disease
Atrophy
Brain - physiopathology
Brain Mapping
Cerebral Cortex - pathology
Female
Functional connectivity
Functional Laterality
Gyrus Cinguli - physiopathology
Humans
Hypertension
Hypertension - physiopathology
Internal Medicine
Magnetic Resonance Imaging - methods
Male
Middle Aged
Resting-state functional MRI
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Description
Summary:Highlights • We compared resting-state functional connectivity in AD with vs. without hypertension. • We observed reduced connectivity between ACC and PCC in hypertension group. • Our results suggest that hypertension may cause further pathologies in AD brains.
ISSN:0167-4943
1872-6976
DOI:10.1016/j.archger.2014.09.012