pH-sensitive poly(glutamic acid) grafted mesoporous silica nanoparticles for drug delivery

pH-sensitive poly(l-glutamic acid) grafted mesoporous silica nanoparticles (MSN-PLGA) were prepared by the surface-initiated N-carboxyanhydride polymerization method. The resultant MSN-PLGA was well dispersed in aqueous medium and showed high drug loading efficiency, superior stability, and signific...

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Bibliographic Details
Published in:International journal of pharmaceutics 2013-06, Vol.450 (1-2), p.296-303
Main Authors: Zheng, Jin, Tian, Xuejiao, Sun, Yangfei, Lu, Daru, Yang, Wuli
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - chemistry
Cell Survival - drug effects
DOX
Doxorubicin - administration & dosage
Doxorubicin - chemistry
Drug delivery
Drug Delivery Systems
HeLa Cells
Humans
Hydrogen-Ion Concentration
Mesoporous silica nanoparticle
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Osmolar Concentration
Particle Size
pH-sensitive
Poly(l-glutamic acid)
Polyglutamic Acid - chemistry
Silicon Dioxide - chemistry
Spectroscopy, Fourier Transform Infrared
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Summary:pH-sensitive poly(l-glutamic acid) grafted mesoporous silica nanoparticles (MSN-PLGA) were prepared by the surface-initiated N-carboxyanhydride polymerization method. The resultant MSN-PLGA was well dispersed in aqueous medium and showed high drug loading efficiency, superior stability, and significantly higher drug release rates. The cumulative release of doxorubicin hydrochloride (DOX) from DOX-loaded MSN-PLGA (DOX@MSN-PLGA) was pH-dependent and the release rate was much higher at pH 5.5 than that at pH 7.4. The cytotoxicity results indicated that the blank MSN-PLGA was biocompatible and the DOX@MSN-PLGA had potent in vitro cytotoxicity effect similar to free DOX. Overall, these results demonstrate that MSN-PLGA is a promising platform to build pH controlled drug delivery systems for cancer therapy.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2013.04.014