Safe administration of a gelatin-containing vaccine in an adult with galactose-α-1,3-galactose allergy

Abstract Immunoglobulin (Ig) E antibodies to galactose-α-1,3-galactose (α-Gal) are associated with delayed anaphylaxis to mammalian food products and gelatin-based foods (Commins et al., J Allergy Clin Immunol 2009;123:426; Caponetto et al., J Allergy Clin Immunol Pract 2013;1:302). We describe a pa...

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Bibliographic Details
Published in:Vaccine 2015-03, Vol.33 (10), p.1231-1232
Main Authors: Pinson, Michelle L, Waibel, Kirk H
Format: Article
Language:English
Subjects:
Allergens - immunology
Allergy and Immunology
Anaphylaxis - immunology
Disaccharides - immunology
Food Hypersensitivity - immunology
Gelatin
Gelatin - immunology
Gelatin - therapeutic use
Herpes Zoster Vaccine - immunology
Herpes Zoster Vaccine - therapeutic use
Humans
Hypersensitivity, Delayed - immunology
Immunoglobulin E - immunology
Male
Meat - adverse effects
Middle Aged
Red meat allergy
Skin Tests
Vaccine, α-Gal allergy
Vaccines, Attenuated - immunology
Vaccines, Attenuated - therapeutic use
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Summary:Abstract Immunoglobulin (Ig) E antibodies to galactose-α-1,3-galactose (α-Gal) are associated with delayed anaphylaxis to mammalian food products and gelatin-based foods (Commins et al., J Allergy Clin Immunol 2009;123:426; Caponetto et al., J Allergy Clin Immunol Pract 2013;1:302). We describe a patient with α-Gal allergy who successfully tolerated the live zoster vaccine and we review anaphylactic reactions reported to this vaccine. Our patient, who tolerated a vaccine containing the highest gelatin content, is reassuring but continued safety assessment of gelatin-containing vaccines for this patient cohort is recommended as there are multiple factors for this patient cohort that influence the reaction risk.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.01.020