Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma

Ubiquitin-specific peptidase 22 (USP22) was recently identified as a new tumor cell marker, and previous studies demonstrated its expression in a variety of tumors and its correlation with tumor progression. Because tumor progression plays an important role in cancer, researchers are paying more att...

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Published in:Translational research : the journal of laboratory and clinical medicine 2015-03, Vol.165 (3), p.407-416
Main Authors: He, Yan, Jin, Yin-Ji, Zhang, Yu-Hua, Meng, Hong-Xue, Zhao, Bao-Shan, Jiang, Yang, Zhu, Ji-Wei, Liang, Guan-Ying, Kong, Dan, Jin, Xiao-Ming
Format: Article
Language:English
Subjects:
Adult
Disease Progression
Female
Fluorescent Antibody Technique
Humans
Internal Medicine
Male
Middle Aged
Paraffin Embedding
Prognosis
Proto-Oncogene Proteins c-myc - metabolism
Stomach Neoplasms - enzymology
Stomach Neoplasms - pathology
Thiolester Hydrolases - metabolism
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Summary:Ubiquitin-specific peptidase 22 (USP22) was recently identified as a new tumor cell marker, and previous studies demonstrated its expression in a variety of tumors and its correlation with tumor progression. Because tumor progression plays an important role in cancer, researchers are paying more attention to the correlation between USP22 expression and metastatic potential, resistance to chemotherapy, and patient prognosis. This study showed that USP22 is highly expressed in gastric cancer tissues, and significant differences in USP22 expression ( P  
ISSN:1931-5244
1878-1810
DOI:10.1016/j.trsl.2014.09.005