Role of neurochemical navigation with 5-aminolevulinic acid during intraoperative MRI-guided resection of intracranial malignant gliomas

Highlights • 5-ALA reveals tumor extension beyond its boundaries on intraoperative MRI. • Intraoperative MRI and 5-ALA have complimentary role during brain tumor resection. • Aggressive resection of malignant gliomas results in high early morbidity rate. • Morbidity at 3 months after aggressive rese...

Full description

Saved in:
Bibliographic Details
Published in:Clinical neurology and neurosurgery 2015-03, Vol.130, p.134-139
Main Authors: Yamada, Shinobu, Muragaki, Yoshihiro, Maruyama, Takashi, Komori, Takashi, Okada, Yoshikazu
Format: Article
Language:English
Subjects:
5-ALA
Adolescent
Adult
Aged
Aged, 80 and over
Aminolevulinic Acid
Brain cancer
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Confidence intervals
Female
Fluorescent Dyes
Glioma - pathology
Glioma - surgery
Humans
Intraoperative MRI
Magnetic Resonance Imaging - methods
Male
Malignant glioma
Medical prognosis
Middle Aged
Neurochemical navigation
Neurology
Neuronavigation
Neurosurgery
Neurosurgical Procedures - methods
Photodynamic diagnosis
Postoperative period
Surgery
Surgical resection
Tumors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • 5-ALA reveals tumor extension beyond its boundaries on intraoperative MRI. • Intraoperative MRI and 5-ALA have complimentary role during brain tumor resection. • Aggressive resection of malignant gliomas results in high early morbidity rate. • Morbidity at 3 months after aggressive resection of gliomas seems acceptable.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2015.01.005