Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications

Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer w...

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Bibliographic Details
Published in:Applied radiation and isotopes 2015-04, Vol.98, p.7-12
Main Authors: Černoch, Peter, Černochová, Zulfiya, Kučka, Jan, Hrubý, Martin, Petrova, Svetlana, Štěpánek, Petr
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Brachytherapy
Brachytherapy - methods
Caprolactam - analogs & derivatives
Caprolactam - chemistry
Humans
Iodine Radioisotopes - therapeutic use
Materials Testing
Methacrylates - chemistry
Neoplasms - radiotherapy
Poly(N-vinylcaprolactam)
Polymers - chemistry
Solubility
Temperature
Thermosensitive polymer
Tumor
Tyrosine - analogs & derivatives
Tyrosine - chemistry
Water
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Summary:Brachytherapy represents effective local therapy of unresectable solid tumors with very few side effects. Radiolabeled thermoresponsive polymers offer almost noninvasive approach to brachytherapy applications. A radioiodinated, water-soluble, thermosensitive poly(N-vinylcaprolactam) (PVCL) polymer was prepared using two approaches. The direct copolymerization with N-methacryloyl-l-tyrosinamide, as well as end-capping of carboxy-terminated PVCL homopolymer with tyramine, were used. In both cases the product was successfully radiolabeled with 125I. The obtained polymers demonstrate cloud-point temperature (TC) values in the range of 33–35°C in all the studied solvent systems (water, PBS (pH 7.4) and physiological saline solution). Above the cloud point temperature, the molecularly dissolved polymer is macroprecipitated from the solution. The TC values close to the human body temperature of this biocompatible poly(N-vinylcaprolactam) polymer makes it a promising material intended for local therapy of solid tumors. •New radiolabeled thermoresponsive polymer system for injectable brachytherapy is described.•Two ways of introducing radiolabelable moiety into poly(N-vinylcaprolactam) are demonstrated.•The method allows preparation of a stable product carrying 125I.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2015.01.005