Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats

Neurogenic inflammation in the dura mater caused by trigeminal nociceptive activation has been implicated in the pathophysiology of migraine. Vasoactive intestinal polypeptide (VIP) is a powerful neuroprotective neuropeptide that can modulate mast cell behavior. Migraine is also associated with symp...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroscience research 2015-04, Vol.93 (4), p.644-650
Main Authors: Kilinc, Erkan, Firat, Tülin, Tore, Fatma, Kiyan, Aysu, Kukner, Aysel, Tunçel, Nese
Format: Article
Language:English
Subjects:
and inflammation
Animals
Dura Mater - cytology
Male
mast cell
Mast Cells - drug effects
migraine
Oncogene Proteins v-fos - metabolism
Rats
Rats, Sprague-Dawley
Statistics, Nonparametric
Sympathectomy
Trigeminal Nuclei - drug effects
Trigeminal Nuclei - metabolism
Vasoactive Intestinal Peptide - pharmacology
VIP
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4603-9affd24a9128a371e1c2125afaeea31b12dad3c41c585a8661eaa18cb2181df73
cites
container_end_page 650
container_issue 4
container_start_page 644
container_title Journal of neuroscience research
container_volume 93
creator Kilinc, Erkan
Firat, Tülin
Tore, Fatma
Kiyan, Aysu
Kukner, Aysel
Tunçel, Nese
description Neurogenic inflammation in the dura mater caused by trigeminal nociceptive activation has been implicated in the pathophysiology of migraine. Vasoactive intestinal polypeptide (VIP) is a powerful neuroprotective neuropeptide that can modulate mast cell behavior. Migraine is also associated with sympathetic insufficiency. This study investigates the effects of VIP on the number of mast cells in the dura mater and on c‐Fos expression in the trigeminal nucleus of sympathectomized rats. Experiments were carried out with 32 Sprague‐Dawley male rats with body weights of 200–250 g. In the sympathectomized group, the left superior cervical sympathetic ganglion was removed. In the sympathectomized + VIP group, postoperative VIP 25 ng/kg/day (0.2 ml) was administered for 5 days. In the sham group, the ganglion and nerves were exposed but not dissected. Dura maters were stained with toluidine blue, and brainstems were labeled by indirect immunohistochemistry for c‐Fos. Sympathectomy significantly increased the number of mast cells in both the ipsilateral and the contralateral dura mater (P 
doi_str_mv 10.1002/jnr.23523
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660417269</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1660417269</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4603-9affd24a9128a371e1c2125afaeea31b12dad3c41c585a8661eaa18cb2181df73</originalsourceid><addsrcrecordid>eNqNkc9vFCEUx4nR2LV68B8wJF68TMuDgZk5amNrTbOmRuuRvAVGWeeXwKjr1X9cdrb24MkLkPc-H8LjS8hTYCfAGD_dDuGEC8nFPbIC1lRFKcvqPlkxoVhRMuBH5FGMW8ZY00jxkBzx3Fec1Svy-wbjiCb5745eDsnF5Afs6OSm5K2j_WjnDnOZmuJ8jHQhfdpRP9D0xdEU_GfXL8owm87NGRkstXNA2mcv5DUmalzXxb0Td_2EWTRp7P0vZ2nAFB-TBy120T253Y_Jx_PXH87eFFfvLi7PXl4VplRMFA22reUlNsBrFBU4MBy4xBadQwEb4BatMCUYWUuslQKHCLXZcKjBtpU4Ji8O905h_DbnUXXv4_5pOLhxjhqUYiVUXDX_gUopOWeyzOjzf9DtOIf8IwtVVgKY2lPPbql50zurp-B7DDv9N4kMnB6AH75zu7s-ML2PWOeI9RKxfrt-vxyyURwMH5P7eWdg-KpVJSqpP60v9PoVVDfs-lqD-AO-Xqj2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1654731064</pqid></control><display><type>article</type><title>Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Kilinc, Erkan ; Firat, Tülin ; Tore, Fatma ; Kiyan, Aysu ; Kukner, Aysel ; Tunçel, Nese</creator><creatorcontrib>Kilinc, Erkan ; Firat, Tülin ; Tore, Fatma ; Kiyan, Aysu ; Kukner, Aysel ; Tunçel, Nese</creatorcontrib><description>Neurogenic inflammation in the dura mater caused by trigeminal nociceptive activation has been implicated in the pathophysiology of migraine. Vasoactive intestinal polypeptide (VIP) is a powerful neuroprotective neuropeptide that can modulate mast cell behavior. Migraine is also associated with sympathetic insufficiency. This study investigates the effects of VIP on the number of mast cells in the dura mater and on c‐Fos expression in the trigeminal nucleus of sympathectomized rats. Experiments were carried out with 32 Sprague‐Dawley male rats with body weights of 200–250 g. In the sympathectomized group, the left superior cervical sympathetic ganglion was removed. In the sympathectomized + VIP group, postoperative VIP 25 ng/kg/day (0.2 ml) was administered for 5 days. In the sham group, the ganglion and nerves were exposed but not dissected. Dura maters were stained with toluidine blue, and brainstems were labeled by indirect immunohistochemistry for c‐Fos. Sympathectomy significantly increased the number of mast cells in both the ipsilateral and the contralateral dura mater (P &lt; 0.001). VIP decreased the number of mast cells in both sides of the dura mater in sympathectomized rats. VIP also decreased c‐Fos expression in the ipsilateral trigeminal nucleus of sympathectomized rats (P &lt; 0.001). In the context of an experimental superior cervical ganglionectomy model of migraine, VIP is an efficient modulator of neurogenic inflammation of the dura. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.23523</identifier><identifier>PMID: 25476208</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>and inflammation ; Animals ; Dura Mater - cytology ; Male ; mast cell ; Mast Cells - drug effects ; migraine ; Oncogene Proteins v-fos - metabolism ; Rats ; Rats, Sprague-Dawley ; Statistics, Nonparametric ; Sympathectomy ; Trigeminal Nuclei - drug effects ; Trigeminal Nuclei - metabolism ; Vasoactive Intestinal Peptide - pharmacology ; VIP</subject><ispartof>Journal of neuroscience research, 2015-04, Vol.93 (4), p.644-650</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4603-9affd24a9128a371e1c2125afaeea31b12dad3c41c585a8661eaa18cb2181df73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25476208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kilinc, Erkan</creatorcontrib><creatorcontrib>Firat, Tülin</creatorcontrib><creatorcontrib>Tore, Fatma</creatorcontrib><creatorcontrib>Kiyan, Aysu</creatorcontrib><creatorcontrib>Kukner, Aysel</creatorcontrib><creatorcontrib>Tunçel, Nese</creatorcontrib><title>Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats</title><title>Journal of neuroscience research</title><addtitle>Journal of Neuroscience Research</addtitle><description>Neurogenic inflammation in the dura mater caused by trigeminal nociceptive activation has been implicated in the pathophysiology of migraine. Vasoactive intestinal polypeptide (VIP) is a powerful neuroprotective neuropeptide that can modulate mast cell behavior. Migraine is also associated with sympathetic insufficiency. This study investigates the effects of VIP on the number of mast cells in the dura mater and on c‐Fos expression in the trigeminal nucleus of sympathectomized rats. Experiments were carried out with 32 Sprague‐Dawley male rats with body weights of 200–250 g. In the sympathectomized group, the left superior cervical sympathetic ganglion was removed. In the sympathectomized + VIP group, postoperative VIP 25 ng/kg/day (0.2 ml) was administered for 5 days. In the sham group, the ganglion and nerves were exposed but not dissected. Dura maters were stained with toluidine blue, and brainstems were labeled by indirect immunohistochemistry for c‐Fos. Sympathectomy significantly increased the number of mast cells in both the ipsilateral and the contralateral dura mater (P &lt; 0.001). VIP decreased the number of mast cells in both sides of the dura mater in sympathectomized rats. VIP also decreased c‐Fos expression in the ipsilateral trigeminal nucleus of sympathectomized rats (P &lt; 0.001). In the context of an experimental superior cervical ganglionectomy model of migraine, VIP is an efficient modulator of neurogenic inflammation of the dura. © 2014 Wiley Periodicals, Inc.</description><subject>and inflammation</subject><subject>Animals</subject><subject>Dura Mater - cytology</subject><subject>Male</subject><subject>mast cell</subject><subject>Mast Cells - drug effects</subject><subject>migraine</subject><subject>Oncogene Proteins v-fos - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Statistics, Nonparametric</subject><subject>Sympathectomy</subject><subject>Trigeminal Nuclei - drug effects</subject><subject>Trigeminal Nuclei - metabolism</subject><subject>Vasoactive Intestinal Peptide - pharmacology</subject><subject>VIP</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkc9vFCEUx4nR2LV68B8wJF68TMuDgZk5amNrTbOmRuuRvAVGWeeXwKjr1X9cdrb24MkLkPc-H8LjS8hTYCfAGD_dDuGEC8nFPbIC1lRFKcvqPlkxoVhRMuBH5FGMW8ZY00jxkBzx3Fec1Svy-wbjiCb5745eDsnF5Afs6OSm5K2j_WjnDnOZmuJ8jHQhfdpRP9D0xdEU_GfXL8owm87NGRkstXNA2mcv5DUmalzXxb0Td_2EWTRp7P0vZ2nAFB-TBy120T253Y_Jx_PXH87eFFfvLi7PXl4VplRMFA22reUlNsBrFBU4MBy4xBadQwEb4BatMCUYWUuslQKHCLXZcKjBtpU4Ji8O905h_DbnUXXv4_5pOLhxjhqUYiVUXDX_gUopOWeyzOjzf9DtOIf8IwtVVgKY2lPPbql50zurp-B7DDv9N4kMnB6AH75zu7s-ML2PWOeI9RKxfrt-vxyyURwMH5P7eWdg-KpVJSqpP60v9PoVVDfs-lqD-AO-Xqj2</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Kilinc, Erkan</creator><creator>Firat, Tülin</creator><creator>Tore, Fatma</creator><creator>Kiyan, Aysu</creator><creator>Kukner, Aysel</creator><creator>Tunçel, Nese</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats</title><author>Kilinc, Erkan ; Firat, Tülin ; Tore, Fatma ; Kiyan, Aysu ; Kukner, Aysel ; Tunçel, Nese</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4603-9affd24a9128a371e1c2125afaeea31b12dad3c41c585a8661eaa18cb2181df73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>and inflammation</topic><topic>Animals</topic><topic>Dura Mater - cytology</topic><topic>Male</topic><topic>mast cell</topic><topic>Mast Cells - drug effects</topic><topic>migraine</topic><topic>Oncogene Proteins v-fos - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Statistics, Nonparametric</topic><topic>Sympathectomy</topic><topic>Trigeminal Nuclei - drug effects</topic><topic>Trigeminal Nuclei - metabolism</topic><topic>Vasoactive Intestinal Peptide - pharmacology</topic><topic>VIP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kilinc, Erkan</creatorcontrib><creatorcontrib>Firat, Tülin</creatorcontrib><creatorcontrib>Tore, Fatma</creatorcontrib><creatorcontrib>Kiyan, Aysu</creatorcontrib><creatorcontrib>Kukner, Aysel</creatorcontrib><creatorcontrib>Tunçel, Nese</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kilinc, Erkan</au><au>Firat, Tülin</au><au>Tore, Fatma</au><au>Kiyan, Aysu</au><au>Kukner, Aysel</au><au>Tunçel, Nese</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>Journal of Neuroscience Research</addtitle><date>2015-04</date><risdate>2015</risdate><volume>93</volume><issue>4</issue><spage>644</spage><epage>650</epage><pages>644-650</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>Neurogenic inflammation in the dura mater caused by trigeminal nociceptive activation has been implicated in the pathophysiology of migraine. Vasoactive intestinal polypeptide (VIP) is a powerful neuroprotective neuropeptide that can modulate mast cell behavior. Migraine is also associated with sympathetic insufficiency. This study investigates the effects of VIP on the number of mast cells in the dura mater and on c‐Fos expression in the trigeminal nucleus of sympathectomized rats. Experiments were carried out with 32 Sprague‐Dawley male rats with body weights of 200–250 g. In the sympathectomized group, the left superior cervical sympathetic ganglion was removed. In the sympathectomized + VIP group, postoperative VIP 25 ng/kg/day (0.2 ml) was administered for 5 days. In the sham group, the ganglion and nerves were exposed but not dissected. Dura maters were stained with toluidine blue, and brainstems were labeled by indirect immunohistochemistry for c‐Fos. Sympathectomy significantly increased the number of mast cells in both the ipsilateral and the contralateral dura mater (P &lt; 0.001). VIP decreased the number of mast cells in both sides of the dura mater in sympathectomized rats. VIP also decreased c‐Fos expression in the ipsilateral trigeminal nucleus of sympathectomized rats (P &lt; 0.001). In the context of an experimental superior cervical ganglionectomy model of migraine, VIP is an efficient modulator of neurogenic inflammation of the dura. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25476208</pmid><doi>10.1002/jnr.23523</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0360-4012
ispartof Journal of neuroscience research, 2015-04, Vol.93 (4), p.644-650
issn 0360-4012
1097-4547
language eng
recordid cdi_proquest_miscellaneous_1660417269
source Wiley-Blackwell Read & Publish Collection
subjects and inflammation
Animals
Dura Mater - cytology
Male
mast cell
Mast Cells - drug effects
migraine
Oncogene Proteins v-fos - metabolism
Rats
Rats, Sprague-Dawley
Statistics, Nonparametric
Sympathectomy
Trigeminal Nuclei - drug effects
Trigeminal Nuclei - metabolism
Vasoactive Intestinal Peptide - pharmacology
VIP
title Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T13%3A16%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vasoactive%20Intestinal%20peptide%20modulates%20c-Fos%20activity%20in%20the%20trigeminal%20nucleus%20and%20dura%20mater%20mast%20cells%20in%20sympathectomized%20rats&rft.jtitle=Journal%20of%20neuroscience%20research&rft.au=Kilinc,%20Erkan&rft.date=2015-04&rft.volume=93&rft.issue=4&rft.spage=644&rft.epage=650&rft.pages=644-650&rft.issn=0360-4012&rft.eissn=1097-4547&rft_id=info:doi/10.1002/jnr.23523&rft_dat=%3Cproquest_pubme%3E1660417269%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4603-9affd24a9128a371e1c2125afaeea31b12dad3c41c585a8661eaa18cb2181df73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1654731064&rft_id=info:pmid/25476208&rfr_iscdi=true