Evaluation of Biochemical Parameters and Local and Systemic Levels of Osteoactive and B‐Cell Stimulatory Factors in Gestational Diabetes in the Presence or Absence of Gingivitis

• Published in: Journal of periodontology (1970) 2015-03, Vol.86 (3), p.387-397
• Main Authors: Gümüş, Pınar, Özçaka, Özgün, Ceyhan‐Öztürk, Banu, Akcali, Aliye, Lappin, David F., Buduneli, Nurcan
• Format: Article
• Language: English
• Subjects: Adult; B-Cell Activating Factor - analysis; B-Cell Activating Factor - blood; Body Mass Index; B‐cell activating factor; Dental Plaque Index; Dentistry; diabetes, gestational; Diabetes, Gestational - blood; Diabetes, Gestational - immunology; Female; Gingival Crevicular Fluid - immunology; gingivitis; Gingivitis - blood; Gingivitis - immunology; Glucose Tolerance Test; Humans; Interleukin-6 - analysis; Interleukin-6 - blood; interleukins; Interleukins - analysis; Maternal Age; osteoprotegerin; Osteoprotegerin - analysis; Osteoprotegerin - blood; Periodontal Index; Periodontal Pocket - immunology; Pregnancy; RANK Ligand - analysis; RANK Ligand - blood; Saliva - immunology; tumor necrosis factor ligand superfamily member 13; Tumor Necrosis Factor Ligand Superfamily Member 13 - analysis; Tumor Necrosis Factor Ligand Superfamily Member 13 - blood
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1902/jop.2014.140444

Background: Gestational diabetes mellitus (GDM) is defined as varying glucose intolerance, with first onset or recognition in pregnancy. This study evaluates clinical and biochemical parameters in a possible association between GDM and gingivitis. Methods: A total of 167 pregnant females was included in the study. There were 101 females with GDM and 66 females without GDM. Subgroups were created according to the presence or absence of gingival inflammation. Plaque index, bleeding on probing, and probing depth were recorded at four sites per tooth. Serum, saliva, and gingival crevicular fluid (GCF) levels of interleukin (IL)‐6, IL‐8, soluble receptor activator of nuclear factor‐kappa B ligand (sRANKL), osteoprotegerin (OPG), B‐cell activating factor (BAFF), and a proliferation‐inducing ligand (APRIL) were determined by enzyme‐linked immunosorbent assay. Data were analyzed by Kruskal‐Wallis and Mann‐Whitney U tests and Spearman correlation analysis. Results: Age and anthropometric indices were higher in the GDM than non‐GDM group (P