High levels of CD4 super(+) CTLA-4 super(+) Treg cells and CCR5 density in HIV-1-infected patients with visceral leishmaniasis

Visceral leishmaniasis (VL) in HIV-1-infected patients has been associated with poor immunological recovery and frequent disease relapses. The aim of this study was to analyse the role of T cell populations, Treg cells and CCR5 density in patients with VL compared to HIV-1-infected patients without...

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Published in:European journal of clinical microbiology & infectious diseases 2015-02, Vol.34 (2), p.267-275
Main Authors: Vallejo, A, Abad-Fernandez, M, Moreno, S, Moreno, A, Perez-Elias, MJ, Dronda, F, Casado, J L
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Human immunodeficiency virus
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container_title European journal of clinical microbiology & infectious diseases
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creator Vallejo, A
Abad-Fernandez, M
Moreno, S
Moreno, A
Perez-Elias, MJ
Dronda, F
Casado, J L
description Visceral leishmaniasis (VL) in HIV-1-infected patients has been associated with poor immunological recovery and frequent disease relapses. The aim of this study was to analyse the role of T cell populations, Treg cells and CCR5 density in patients with VL compared to HIV-1-infected patients without leishmaniasis. A cross-sectional study of nine Leishmania-HIV-1-coinfected (LH) patients with VL receiving suppressive cART for at least 1 year were compared to 16 HIV-1-infected patients with non-immunological response (NIR, CD4 count below 250 cells/mm super(3)) and 26 HIV-1-infected patients with immunological response (IR, CD4 count above 500 cells/mm super(3)) without leishmaniasis. LH patients had a deep depletion of naive T cells (p=0.002), despite similar levels of effector T cells compared to NIR patients. CD4 Treg cells were similar compared to NIR patients, but higher compared to IR patients (p
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The aim of this study was to analyse the role of T cell populations, Treg cells and CCR5 density in patients with VL compared to HIV-1-infected patients without leishmaniasis. A cross-sectional study of nine Leishmania-HIV-1-coinfected (LH) patients with VL receiving suppressive cART for at least 1 year were compared to 16 HIV-1-infected patients with non-immunological response (NIR, CD4 count below 250 cells/mm super(3)) and 26 HIV-1-infected patients with immunological response (IR, CD4 count above 500 cells/mm super(3)) without leishmaniasis. LH patients had a deep depletion of naive T cells (p=0.002), despite similar levels of effector T cells compared to NIR patients. CD4 Treg cells were similar compared to NIR patients, but higher compared to IR patients (p&lt;0.001). Interestingly, CD4 Treg CTLA-4 super(+) cells were higher in LH patients compared to either NIR or IR patients (p=0.022 and p&lt;0.001, respectively), and the CD4 Treg/TEM ratio was similar to NIR patients, but higher compared to IR patients (p=0.017). CCR5 super(+) T cell levels were higher compared to IR patients (p&lt;0.001), while CCR5 density on T cells were higher compared to both NIR and IR patients (p&lt;0.005 in both cases). Higher levels of CD4 super(+) CTLA-4 super(+) Treg cells and CCR5 density on CD8 super(+) T cells are strongly associated with VL in HIV-1-infected patients. 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subjects Human immunodeficiency virus
title High levels of CD4 super(+) CTLA-4 super(+) Treg cells and CCR5 density in HIV-1-infected patients with visceral leishmaniasis
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