The epidemiological profile of ASIA syndrome after HPV vaccination: an evaluation based on the Vaccine Adverse Event Reporting Systems

The term “ASIA—Autoimmune/inflammatory Syndrome Induced by Adjuvants” describes an umbrella of clinical conditions sharing similar signs or symptoms, including post-vaccination phenomena. No information is available on the epidemiology of the ASIA syndrome, especially following HPV vaccination. We c...

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Bibliographic Details
Published in:Immunologic research 2015-02, Vol.61 (1-2), p.90-96
Main Authors: Pellegrino, Paolo, Perrone, Valentina, Pozzi, Marco, Carnovale, Carla, Perrotta, Cristiana, Clementi, Emilio, Radice, Sonia
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - adverse effects
Adolescent
Adult
Allergology
Autoimmune Diseases - diagnosis
Autoimmune Diseases - epidemiology
Autoimmune Diseases - etiology
Biomedical and Life Sciences
Biomedicine
Child
Cutting Edge in Autoimmunity
Databases, Factual
Epidemiology
Female
Human papillomavirus
Humans
Immunology
Inflammation - diagnosis
Inflammation - epidemiology
Inflammation - etiology
Internal Medicine
Male
Medicine/Public Health
Papillomavirus Vaccines - adverse effects
Syndrome
United States - epidemiology
Vaccines
Young Adult
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Summary:The term “ASIA—Autoimmune/inflammatory Syndrome Induced by Adjuvants” describes an umbrella of clinical conditions sharing similar signs or symptoms, including post-vaccination phenomena. No information is available on the epidemiology of the ASIA syndrome, especially following HPV vaccination. We carried out an analysis of the VAERS database to retrieve all cases of suspected ASIA syndrome according to the Shoenfeld and Agmon-Levin’s guideline for the diagnosis. After causality assessment and case validation, 2,207 cases were considered probably or possibly related to vaccination. These represent the largest ASIA cohort ever reported and allowed us to estimate epidemiological and clinical characteristic of this syndrome. The commonest clinical manifestation observed were pyrexia (58 %), myalgia (27 %) and arthralgia or arthritis (19 %), and the estimated reporting rate was of 3.6 cases per 100,000 doses of HPV vaccine distributed (95 % CI 3.4–3.7). This study presents the first systematic estimation of ASIA incidence and expands the knowledge on this pathology. Further analyses are needed to identify genetic and non-genetic risk factors for ASIA syndrome.
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-014-8567-3