Glucose or intermittent high-intensity exercise in glargine/glulisine users with T1DM

The effects of glargine/glulisine insulin regimen on exercise blood glucose (BG) and strategies to limit exercise-induced hypoglycemia are not well documented. Intermittent high-intensity exercise has been proposed to prevent hypoglycemia, but its effect in participants with type 1 diabetes using gl...

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Bibliographic Details
Published in:Medicine and science in sports and exercise 2013-01, Vol.45 (1), p.3-7
Main Authors: Dubé, Marie-Christine, Lavoie, Carole, Weisnagel, S John
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Blood Glucose - metabolism
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - physiopathology
Exercise - physiology
Exercise Test
Female
Glucose - therapeutic use
Humans
Hypoglycemia - diagnosis
Hypoglycemia - etiology
Hypoglycemia - prevention & control
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - therapeutic use
Insulin - adverse effects
Insulin - analogs & derivatives
Insulin - therapeutic use
Insulin Glargine
Insulin, Long-Acting - adverse effects
Insulin, Long-Acting - therapeutic use
Male
Space life sciences
Treatment Outcome
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Summary:The effects of glargine/glulisine insulin regimen on exercise blood glucose (BG) and strategies to limit exercise-induced hypoglycemia are not well documented. Intermittent high-intensity exercise has been proposed to prevent hypoglycemia, but its effect in participants with type 1 diabetes using glargine/glulisine is unknown. The study used a repeated-measures design with three randomly ordered exercise conditions. Eleven participants completed 60 min of moderate-intensity exercise at 50% VO(2peak) for all conditions. These conditions varied as follows: participants ingested 0 g of glucose preexercise (0G + MOD), 30 g of glucose preexercise (30G + MOD), or 0 g of glucose preexercise but performed brief high-intensity intervals interspersed every 2 min (0G + MOD/INT) during exercise. If BG fell
ISSN:0195-9131
1530-0315
DOI:10.1249/MSS.0b013e31826c6ad3