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Rapid immunohistochemistry based on alternating current electric field for intraoperative diagnosis of brain tumors
Rapid immunohistochemistry (R-IHC) can contribute to the intraoperative diagnosis of central nervous system (CNS) tumors. We have recently developed a new IHC method based on an alternating current electric field to facilitate the antigen–antibody reaction. To ensure the requirement of R-IHC for int...
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| Published in: | Brain tumor pathology 2015-01, Vol.32 (1), p.12-19 |
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| creator | Tanino, Mishie Sasajima, Toshio Nanjo, Hiroshi Akesaka, Shiori Kagaya, Masami Kimura, Taichi Ishida, Yusuke Oda, Masaya Takahashi, Masataka Sugawara, Taku Yoshioka, Toshiaki Nishihara, Hiroshi Akagami, Yoichi Goto, Akiteru Minamiya, Yoshihiro Tanaka, Shinya |
| description | Rapid immunohistochemistry (R-IHC) can contribute to the intraoperative diagnosis of central nervous system (CNS) tumors. We have recently developed a new IHC method based on an alternating current electric field to facilitate the antigen–antibody reaction. To ensure the requirement of R-IHC for intraoperative diagnosis, 183 cases of CNS tumors were reviewed regarding the accuracy rate of diagnosis without R-IHC. The diagnostic accuracy was 90.7 % (168/183 cases) in which definitive diagnoses were not provided in 17 cases because of the failure of glioma grading and differential diagnosis of lymphoma and glioma. To establish the clinicopathological application, R-IHC for frozen specimens was compared with standard IHC for permanent specimens. 33 gliomas were analyzed, and the Ki-67/MIB-1 indices of frozen specimens by R-IHC were consistent with the grade and statistically correlated with those of permanent specimens. Thus, R-IHC provided supportive information to determine the grade of glioma. For discrimination between glioma and lymphoma, R-IHC was able to provide clear results of CD20 and Ki-67/MIB-1 in four frozen specimens of CNS lymphoma as well as standard IHC. We conclude that the R-IHC for frozen specimens can provide important information for intraoperative diagnosis of CNS tumors. |
| doi_str_mv | 10.1007/s10014-014-0188-y |
| format | article |
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We have recently developed a new IHC method based on an alternating current electric field to facilitate the antigen–antibody reaction. To ensure the requirement of R-IHC for intraoperative diagnosis, 183 cases of CNS tumors were reviewed regarding the accuracy rate of diagnosis without R-IHC. The diagnostic accuracy was 90.7 % (168/183 cases) in which definitive diagnoses were not provided in 17 cases because of the failure of glioma grading and differential diagnosis of lymphoma and glioma. To establish the clinicopathological application, R-IHC for frozen specimens was compared with standard IHC for permanent specimens. 33 gliomas were analyzed, and the Ki-67/MIB-1 indices of frozen specimens by R-IHC were consistent with the grade and statistically correlated with those of permanent specimens. Thus, R-IHC provided supportive information to determine the grade of glioma. For discrimination between glioma and lymphoma, R-IHC was able to provide clear results of CD20 and Ki-67/MIB-1 in four frozen specimens of CNS lymphoma as well as standard IHC. We conclude that the R-IHC for frozen specimens can provide important information for intraoperative diagnosis of CNS tumors.</description><identifier>ISSN: 1433-7398</identifier><identifier>EISSN: 1861-387X</identifier><identifier>DOI: 10.1007/s10014-014-0188-y</identifier><identifier>PMID: 24807101</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Accuracy ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies ; Antigen-Antibody Reactions ; Biomarkers, Tumor - analysis ; Brain cancer ; Brain Neoplasms - diagnosis ; Brain Neoplasms - pathology ; Cancer Research ; Cloning ; Diagnosis, Differential ; Electric fields ; Electricity ; Female ; Frozen Sections ; Glioma ; Glioma - diagnosis ; Glioma - pathology ; Humans ; Immunohistochemistry - methods ; Intraoperative Period ; Ki-67 Antigen - analysis ; Lymphoma ; Lymphoma - diagnosis ; Lymphoma - pathology ; Male ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Neoplasm Staging ; Neurology ; Neurosurgery ; Oncology ; Original Article ; Pathology ; Sensitivity and Specificity ; Stains & staining ; Tumors ; Young Adult</subject><ispartof>Brain tumor pathology, 2015-01, Vol.32 (1), p.12-19</ispartof><rights>The Japan Society of Brain Tumor Pathology 2014</rights><rights>The Japan Society of Brain Tumor Pathology 2014.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c652t-6474c4a6c815122af1d56e5fdd5ee272f74e33588fa63f0271f1dbdfb0fff9383</citedby><cites>FETCH-LOGICAL-c652t-6474c4a6c815122af1d56e5fdd5ee272f74e33588fa63f0271f1dbdfb0fff9383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24807101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanino, Mishie</creatorcontrib><creatorcontrib>Sasajima, Toshio</creatorcontrib><creatorcontrib>Nanjo, Hiroshi</creatorcontrib><creatorcontrib>Akesaka, Shiori</creatorcontrib><creatorcontrib>Kagaya, Masami</creatorcontrib><creatorcontrib>Kimura, Taichi</creatorcontrib><creatorcontrib>Ishida, Yusuke</creatorcontrib><creatorcontrib>Oda, Masaya</creatorcontrib><creatorcontrib>Takahashi, Masataka</creatorcontrib><creatorcontrib>Sugawara, Taku</creatorcontrib><creatorcontrib>Yoshioka, Toshiaki</creatorcontrib><creatorcontrib>Nishihara, Hiroshi</creatorcontrib><creatorcontrib>Akagami, Yoichi</creatorcontrib><creatorcontrib>Goto, Akiteru</creatorcontrib><creatorcontrib>Minamiya, Yoshihiro</creatorcontrib><creatorcontrib>Tanaka, Shinya</creatorcontrib><creatorcontrib>R-IHC Study Group</creatorcontrib><creatorcontrib>R-IHC Study Group</creatorcontrib><title>Rapid immunohistochemistry based on alternating current electric field for intraoperative diagnosis of brain tumors</title><title>Brain tumor pathology</title><addtitle>Brain Tumor Pathol</addtitle><addtitle>Brain Tumor Pathol</addtitle><description>Rapid immunohistochemistry (R-IHC) can contribute to the intraoperative diagnosis of central nervous system (CNS) tumors. We have recently developed a new IHC method based on an alternating current electric field to facilitate the antigen–antibody reaction. To ensure the requirement of R-IHC for intraoperative diagnosis, 183 cases of CNS tumors were reviewed regarding the accuracy rate of diagnosis without R-IHC. The diagnostic accuracy was 90.7 % (168/183 cases) in which definitive diagnoses were not provided in 17 cases because of the failure of glioma grading and differential diagnosis of lymphoma and glioma. To establish the clinicopathological application, R-IHC for frozen specimens was compared with standard IHC for permanent specimens. 33 gliomas were analyzed, and the Ki-67/MIB-1 indices of frozen specimens by R-IHC were consistent with the grade and statistically correlated with those of permanent specimens. Thus, R-IHC provided supportive information to determine the grade of glioma. For discrimination between glioma and lymphoma, R-IHC was able to provide clear results of CD20 and Ki-67/MIB-1 in four frozen specimens of CNS lymphoma as well as standard IHC. We conclude that the R-IHC for frozen specimens can provide important information for intraoperative diagnosis of CNS tumors.</description><subject>Accuracy</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies</subject><subject>Antigen-Antibody Reactions</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Cloning</subject><subject>Diagnosis, Differential</subject><subject>Electric fields</subject><subject>Electricity</subject><subject>Female</subject><subject>Frozen Sections</subject><subject>Glioma</subject><subject>Glioma - diagnosis</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Intraoperative Period</subject><subject>Ki-67 Antigen - analysis</subject><subject>Lymphoma</subject><subject>Lymphoma - diagnosis</subject><subject>Lymphoma - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Sensitivity and Specificity</subject><subject>Stains & staining</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>1433-7398</issn><issn>1861-387X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkU1rFTEUhoMo9kN_gBsJuHEzNl-TZJZSqhUKQrHQXcgkJ7cpM8k1mRHuvzeXqQqC4OJ8wHnOe0hehN5Q8oESoi5qy1R0W2jdHZ6hU6ol7bhW989bLzjvFB_0CTqr9ZEQIYiiL9EJE7o1hJ6iemv30eM4z2vKD7Eu2T3A3Go54NFW8DgnbKcFSrJLTDvs1lIgLRgmcEuJDocIk8chFxzTUmzeQ2nkD8A-2l3KNVacAx6LjQkv65xLfYVeBDtVeP1Uz9Hdp6tvl9fdzdfPXy4_3nRO9mzppFDCCSudpj1lzAbqewl98L4HYIoFJYDzXutgJQ-EKdqI0YeRhBAGrvk5er_p7kv-vkJdTHuYg2myCfJaDZWSCD4IOfwH2jM-qKE_qr77C33Ma_udqRo2UN0UCTtSdKNcybUWCGZf4mzLwVBijuaZzTyzhdbm0HbePimv4wz-98YvtxrANqC2UdpB-XP636o_AfUrpyI</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Tanino, Mishie</creator><creator>Sasajima, Toshio</creator><creator>Nanjo, Hiroshi</creator><creator>Akesaka, Shiori</creator><creator>Kagaya, Masami</creator><creator>Kimura, Taichi</creator><creator>Ishida, Yusuke</creator><creator>Oda, Masaya</creator><creator>Takahashi, Masataka</creator><creator>Sugawara, Taku</creator><creator>Yoshioka, Toshiaki</creator><creator>Nishihara, Hiroshi</creator><creator>Akagami, Yoichi</creator><creator>Goto, Akiteru</creator><creator>Minamiya, Yoshihiro</creator><creator>Tanaka, Shinya</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20150101</creationdate><title>Rapid immunohistochemistry based on alternating current electric field for intraoperative diagnosis of brain tumors</title><author>Tanino, Mishie ; Sasajima, Toshio ; Nanjo, Hiroshi ; Akesaka, Shiori ; Kagaya, Masami ; Kimura, Taichi ; Ishida, Yusuke ; Oda, Masaya ; Takahashi, Masataka ; Sugawara, Taku ; Yoshioka, Toshiaki ; Nishihara, Hiroshi ; Akagami, Yoichi ; Goto, Akiteru ; Minamiya, Yoshihiro ; Tanaka, Shinya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c652t-6474c4a6c815122af1d56e5fdd5ee272f74e33588fa63f0271f1dbdfb0fff9383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Accuracy</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies</topic><topic>Antigen-Antibody Reactions</topic><topic>Biomarkers, Tumor - 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Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain tumor pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanino, Mishie</au><au>Sasajima, Toshio</au><au>Nanjo, Hiroshi</au><au>Akesaka, Shiori</au><au>Kagaya, Masami</au><au>Kimura, Taichi</au><au>Ishida, Yusuke</au><au>Oda, Masaya</au><au>Takahashi, Masataka</au><au>Sugawara, Taku</au><au>Yoshioka, Toshiaki</au><au>Nishihara, Hiroshi</au><au>Akagami, Yoichi</au><au>Goto, Akiteru</au><au>Minamiya, Yoshihiro</au><au>Tanaka, Shinya</au><aucorp>R-IHC Study Group</aucorp><aucorp>R-IHC Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid immunohistochemistry based on alternating current electric field for intraoperative diagnosis of brain tumors</atitle><jtitle>Brain tumor pathology</jtitle><stitle>Brain Tumor Pathol</stitle><addtitle>Brain Tumor Pathol</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>32</volume><issue>1</issue><spage>12</spage><epage>19</epage><pages>12-19</pages><issn>1433-7398</issn><eissn>1861-387X</eissn><abstract>Rapid immunohistochemistry (R-IHC) can contribute to the intraoperative diagnosis of central nervous system (CNS) tumors. We have recently developed a new IHC method based on an alternating current electric field to facilitate the antigen–antibody reaction. To ensure the requirement of R-IHC for intraoperative diagnosis, 183 cases of CNS tumors were reviewed regarding the accuracy rate of diagnosis without R-IHC. The diagnostic accuracy was 90.7 % (168/183 cases) in which definitive diagnoses were not provided in 17 cases because of the failure of glioma grading and differential diagnosis of lymphoma and glioma. To establish the clinicopathological application, R-IHC for frozen specimens was compared with standard IHC for permanent specimens. 33 gliomas were analyzed, and the Ki-67/MIB-1 indices of frozen specimens by R-IHC were consistent with the grade and statistically correlated with those of permanent specimens. Thus, R-IHC provided supportive information to determine the grade of glioma. For discrimination between glioma and lymphoma, R-IHC was able to provide clear results of CD20 and Ki-67/MIB-1 in four frozen specimens of CNS lymphoma as well as standard IHC. We conclude that the R-IHC for frozen specimens can provide important information for intraoperative diagnosis of CNS tumors.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24807101</pmid><doi>10.1007/s10014-014-0188-y</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature |
| subjects | Accuracy Adolescent Adult Aged Aged, 80 and over Antibodies Antigen-Antibody Reactions Biomarkers, Tumor - analysis Brain cancer Brain Neoplasms - diagnosis Brain Neoplasms - pathology Cancer Research Cloning Diagnosis, Differential Electric fields Electricity Female Frozen Sections Glioma Glioma - diagnosis Glioma - pathology Humans Immunohistochemistry - methods Intraoperative Period Ki-67 Antigen - analysis Lymphoma Lymphoma - diagnosis Lymphoma - pathology Male Medicine Medicine & Public Health Metastasis Middle Aged Neoplasm Staging Neurology Neurosurgery Oncology Original Article Pathology Sensitivity and Specificity Stains & staining Tumors Young Adult |
| title | Rapid immunohistochemistry based on alternating current electric field for intraoperative diagnosis of brain tumors |
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