High-throughput analysis of behavior for drug discovery

Drug testing with traditional behavioral assays constitutes a major bottleneck in the development of novel therapies. PsychoGenics developed three comprehensive high-throughput systems, SmartCube®, NeuroCube® and PhenoCube® systems, to increase the efficiency of the drug screening and phenotyping in...

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Bibliographic Details
Published in:European journal of pharmacology 2015-03, Vol.750, p.82-89
Main Authors: Alexandrov, Vadim, Brunner, Dani, Hanania, Taleen, Leahy, Emer
Format: Article
Language:English
Subjects:
Animal models
Animals
Behavior - drug effects
CNS
Computer vision
Disease Progression
Drug Evaluation, Preclinical - instrumentation
Drug Evaluation, Preclinical - methods
Drug screening
High-throughput
High-Throughput Screening Assays - instrumentation
High-Throughput Screening Assays - methods
Humans
Machine learning
NeuroCube
PhenoCube
Phenotype
Preclinical research
Smartcube
Social behavior
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Description
Summary:Drug testing with traditional behavioral assays constitutes a major bottleneck in the development of novel therapies. PsychoGenics developed three comprehensive high-throughput systems, SmartCube®, NeuroCube® and PhenoCube® systems, to increase the efficiency of the drug screening and phenotyping in rodents. These three systems capture different domains of behavior, namely, cognitive, motor, circadian, social, anxiety-like, gait and others, using custom-built computer vision software and machine learning algorithms for analysis. This review exemplifies the use of the three systems and explains how they can advance drug screening with their applications to phenotyping of disease models, drug screening, selection of lead candidates, behavior-driven lead optimization, and drug repurposing.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2014.11.047