Difference in glucagon-like peptide-1 concentrations between C-peptide negative type 1 diabetes mellitus patients and healthy controls

Background The role of glucagon-like peptide-1 (GLP-1) has become a new scientific interest in the field of pathophysiology of type 1 diabetes mellitus (T1DM), but the results of the published studies were contradictory. The aim of our study was therefore to measure fasting and postprandial GLP-1 co...

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Bibliographic Details
Published in:Annals of clinical biochemistry 2015-03, Vol.52 (2), p.220-225
Main Authors: Zibar, Karin, Ćuća, Jadranka Knežević, Blaslov, Kristina, Bulum, Tomislav, Smirčić-Duvnjak, Lea
Format: Article
Language:English
Subjects:
Adult
C-Peptide - blood
Cross-Sectional Studies
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Down-Regulation
Enzyme-Linked Immunosorbent Assay
Fasting
Female
Glucagon-Like Peptide 1 - blood
Hospitals, University
Humans
Hypoglycemic Agents - therapeutic use
Insulin - therapeutic use
Logistic Models
Male
Middle Aged
Outpatient Clinics, Hospital
Postprandial Period
Sex Characteristics
Young Adult
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Summary:Background The role of glucagon-like peptide-1 (GLP-1) has become a new scientific interest in the field of pathophysiology of type 1 diabetes mellitus (T1DM), but the results of the published studies were contradictory. The aim of our study was therefore to measure fasting and postprandial GLP-1 concentrations in T1DM patients and in healthy controls and to examine the difference in those concentrations between the two groups of subjects. Methods The cross-sectional study included 30 C-peptide negative T1DM patients, median age 37 years (20–59), with disease duration 22 years (3–45), and 10 healthy controls, median age 30 years (27–47). Fasting and postprandial total and active GLP-1 concentrations were measured by ELISA (ALPCO, USA). The data were statistically analysed by SPSS, and significance level was accepted at P 
ISSN:0004-5632
1758-1001
DOI:10.1177/0004563214544709