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Flicker-defined form perimetry in glaucoma patients
Purpose To assess the potential of flicker-defined form (FDF) perimetry to detect functional loss in patient groups with beginning glaucoma, and to evaluate the dynamic range of the FDF stimulus in individual patients and at individual test positions. Methods FDF perimetry and standard automated per...
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| Published in: | Graefe's archive for clinical and experimental ophthalmology 2015-03, Vol.253 (3), p.447-455 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
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| creator | Horn, Folkert K. Kremers, Jan Mardin, Christian Y. Jünemann, Anselm G. Adler, Werner Tornow, Ralf P. |
| description | Purpose
To assess the potential of flicker-defined form (FDF) perimetry to detect functional loss in patient groups with beginning glaucoma, and to evaluate the dynamic range of the FDF stimulus in individual patients and at individual test positions.
Methods
FDF perimetry and standard automated perimetry (SAP) were performed at identical test locations (adapted G1 protocol) in 60 healthy subjects and 111 glaucoma patients. All patients showed glaucomatous optic disc appearance. Grouping within the glaucoma cohort was based on SAP-performance: 33 “preperimetric” open-angle glaucoma (OAG) patients, 28 “borderline” OAG (focal defects and SAP-mean defect (MD) |
| doi_str_mv | 10.1007/s00417-014-2887-9 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660446875</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1660446875</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-5e56c5637bca9ad3e6971f01ca3be893cfa15fd1938b29368eae3f070b310b553</originalsourceid><addsrcrecordid>eNp1kE1Lw0AQhhdRbK3-AC8S8OJldSabzSZHEatCwYtCb8tmMymp-ai7yaH_3i2tIoKnOcwz78w8jF0i3CKAuvMACSoOmPA4yxTPj9gUEyG5gnh5zKagYuSZiJcTdub9GgIuJJ6ySSwlYpyLKRPzprYf5HhJVd1RGVW9a6MNubqlwW2juotWjRlt35poY4aausGfs5PKNJ4uDnXG3uePbw_PfPH69PJwv-A2ATlwSTK1MhWqsCY3paA0V1gBWiMKynJhK4OyKjEXWRFuSTMyJCpQUAiEQkoxYzf73I3rP0fyg25rb6lpTEf96DWmKSRJmqkdev0HXfej68J1gZI5pBCwQOGesq733lGlN-FP47YaQe-M6r1RHYzqnVGdh5mrQ_JYtFT-THwrDEC8B3xodStyv1b_m_oFatV_bA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1659060687</pqid></control><display><type>article</type><title>Flicker-defined form perimetry in glaucoma patients</title><source>Springer Nature</source><creator>Horn, Folkert K. ; Kremers, Jan ; Mardin, Christian Y. ; Jünemann, Anselm G. ; Adler, Werner ; Tornow, Ralf P.</creator><creatorcontrib>Horn, Folkert K. ; Kremers, Jan ; Mardin, Christian Y. ; Jünemann, Anselm G. ; Adler, Werner ; Tornow, Ralf P.</creatorcontrib><description>Purpose
To assess the potential of flicker-defined form (FDF) perimetry to detect functional loss in patient groups with beginning glaucoma, and to evaluate the dynamic range of the FDF stimulus in individual patients and at individual test positions.
Methods
FDF perimetry and standard automated perimetry (SAP) were performed at identical test locations (adapted G1 protocol) in 60 healthy subjects and 111 glaucoma patients. All patients showed glaucomatous optic disc appearance. Grouping within the glaucoma cohort was based on SAP-performance: 33 “preperimetric” open-angle glaucoma (OAG) patients, 28 “borderline” OAG (focal defects and SAP-mean defect (MD) <2 dB), 33 “early” OAG (SAP-MD < 5 dB), 17 “advanced” OAG. All participants were experienced in psychophysical and perimetric tests. Defect values and the areas under receiver operating characteristic curves (ROC) in patient groups were statistically compared.
Results
The values of FDF-MD in the preperimetric, borderline, and early OAG group were 2.7 ± 3.4 dB, 5.5 ± 2.6 dB, and 8.5 ± 3.4 dB respectively (all significantly above normal). The percentage of patients exceeding normal FDF-MD was 27.3 %, 60.7 %, and 87.9 % respectively. The age-adjusted FDF-mean defect (MD) of the G1X-protocol was not significantly correlated with refractive error, lens opacity, pupil size, or gender. Occurrence of ceiling effects (inability to detect targets at highest contrast) showed a high correlation with visual field losses (
R
= 0.72,
p
< 0.001). Local analysis indicates that SAP losses exceeding 5 dB could not be distinguished with the FDF technique.
Conclusion
The FDF stimulus was able to detect beginning glaucoma damage. Patients with SAP-MD values exceeding 5 dB should be monitored with conventional perimetry because of its larger dynamic range.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-014-2887-9</identifier><identifier>PMID: 25511293</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aged ; Female ; Glaucoma ; Glaucoma, Open-Angle - diagnosis ; Glaucoma, Open-Angle - physiopathology ; Humans ; Intraocular Pressure - physiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Ophthalmology ; Optic Nerve Diseases - diagnosis ; Optic Nerve Diseases - physiopathology ; Tonometry, Ocular ; Vision Disorders - diagnosis ; Vision Disorders - physiopathology ; Visual Acuity - physiology ; Visual Field Tests - methods ; Visual Fields - physiology</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2015-03, Vol.253 (3), p.447-455</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-5e56c5637bca9ad3e6971f01ca3be893cfa15fd1938b29368eae3f070b310b553</citedby><cites>FETCH-LOGICAL-c405t-5e56c5637bca9ad3e6971f01ca3be893cfa15fd1938b29368eae3f070b310b553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25511293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horn, Folkert K.</creatorcontrib><creatorcontrib>Kremers, Jan</creatorcontrib><creatorcontrib>Mardin, Christian Y.</creatorcontrib><creatorcontrib>Jünemann, Anselm G.</creatorcontrib><creatorcontrib>Adler, Werner</creatorcontrib><creatorcontrib>Tornow, Ralf P.</creatorcontrib><title>Flicker-defined form perimetry in glaucoma patients</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To assess the potential of flicker-defined form (FDF) perimetry to detect functional loss in patient groups with beginning glaucoma, and to evaluate the dynamic range of the FDF stimulus in individual patients and at individual test positions.
Methods
FDF perimetry and standard automated perimetry (SAP) were performed at identical test locations (adapted G1 protocol) in 60 healthy subjects and 111 glaucoma patients. All patients showed glaucomatous optic disc appearance. Grouping within the glaucoma cohort was based on SAP-performance: 33 “preperimetric” open-angle glaucoma (OAG) patients, 28 “borderline” OAG (focal defects and SAP-mean defect (MD) <2 dB), 33 “early” OAG (SAP-MD < 5 dB), 17 “advanced” OAG. All participants were experienced in psychophysical and perimetric tests. Defect values and the areas under receiver operating characteristic curves (ROC) in patient groups were statistically compared.
Results
The values of FDF-MD in the preperimetric, borderline, and early OAG group were 2.7 ± 3.4 dB, 5.5 ± 2.6 dB, and 8.5 ± 3.4 dB respectively (all significantly above normal). The percentage of patients exceeding normal FDF-MD was 27.3 %, 60.7 %, and 87.9 % respectively. The age-adjusted FDF-mean defect (MD) of the G1X-protocol was not significantly correlated with refractive error, lens opacity, pupil size, or gender. Occurrence of ceiling effects (inability to detect targets at highest contrast) showed a high correlation with visual field losses (
R
= 0.72,
p
< 0.001). Local analysis indicates that SAP losses exceeding 5 dB could not be distinguished with the FDF technique.
Conclusion
The FDF stimulus was able to detect beginning glaucoma damage. Patients with SAP-MD values exceeding 5 dB should be monitored with conventional perimetry because of its larger dynamic range.</description><subject>Aged</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Optic Nerve Diseases - diagnosis</subject><subject>Optic Nerve Diseases - physiopathology</subject><subject>Tonometry, Ocular</subject><subject>Vision Disorders - diagnosis</subject><subject>Vision Disorders - physiopathology</subject><subject>Visual Acuity - physiology</subject><subject>Visual Field Tests - methods</subject><subject>Visual Fields - physiology</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kE1Lw0AQhhdRbK3-AC8S8OJldSabzSZHEatCwYtCb8tmMymp-ai7yaH_3i2tIoKnOcwz78w8jF0i3CKAuvMACSoOmPA4yxTPj9gUEyG5gnh5zKagYuSZiJcTdub9GgIuJJ6ySSwlYpyLKRPzprYf5HhJVd1RGVW9a6MNubqlwW2juotWjRlt35poY4aausGfs5PKNJ4uDnXG3uePbw_PfPH69PJwv-A2ATlwSTK1MhWqsCY3paA0V1gBWiMKynJhK4OyKjEXWRFuSTMyJCpQUAiEQkoxYzf73I3rP0fyg25rb6lpTEf96DWmKSRJmqkdev0HXfej68J1gZI5pBCwQOGesq733lGlN-FP47YaQe-M6r1RHYzqnVGdh5mrQ_JYtFT-THwrDEC8B3xodStyv1b_m_oFatV_bA</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Horn, Folkert K.</creator><creator>Kremers, Jan</creator><creator>Mardin, Christian Y.</creator><creator>Jünemann, Anselm G.</creator><creator>Adler, Werner</creator><creator>Tornow, Ralf P.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Flicker-defined form perimetry in glaucoma patients</title><author>Horn, Folkert K. ; Kremers, Jan ; Mardin, Christian Y. ; Jünemann, Anselm G. ; Adler, Werner ; Tornow, Ralf P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-5e56c5637bca9ad3e6971f01ca3be893cfa15fd1938b29368eae3f070b310b553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Optic Nerve Diseases - diagnosis</topic><topic>Optic Nerve Diseases - physiopathology</topic><topic>Tonometry, Ocular</topic><topic>Vision Disorders - diagnosis</topic><topic>Vision Disorders - physiopathology</topic><topic>Visual Acuity - physiology</topic><topic>Visual Field Tests - methods</topic><topic>Visual Fields - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horn, Folkert K.</creatorcontrib><creatorcontrib>Kremers, Jan</creatorcontrib><creatorcontrib>Mardin, Christian Y.</creatorcontrib><creatorcontrib>Jünemann, Anselm G.</creatorcontrib><creatorcontrib>Adler, Werner</creatorcontrib><creatorcontrib>Tornow, Ralf P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horn, Folkert K.</au><au>Kremers, Jan</au><au>Mardin, Christian Y.</au><au>Jünemann, Anselm G.</au><au>Adler, Werner</au><au>Tornow, Ralf P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flicker-defined form perimetry in glaucoma patients</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>253</volume><issue>3</issue><spage>447</spage><epage>455</epage><pages>447-455</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To assess the potential of flicker-defined form (FDF) perimetry to detect functional loss in patient groups with beginning glaucoma, and to evaluate the dynamic range of the FDF stimulus in individual patients and at individual test positions.
Methods
FDF perimetry and standard automated perimetry (SAP) were performed at identical test locations (adapted G1 protocol) in 60 healthy subjects and 111 glaucoma patients. All patients showed glaucomatous optic disc appearance. Grouping within the glaucoma cohort was based on SAP-performance: 33 “preperimetric” open-angle glaucoma (OAG) patients, 28 “borderline” OAG (focal defects and SAP-mean defect (MD) <2 dB), 33 “early” OAG (SAP-MD < 5 dB), 17 “advanced” OAG. All participants were experienced in psychophysical and perimetric tests. Defect values and the areas under receiver operating characteristic curves (ROC) in patient groups were statistically compared.
Results
The values of FDF-MD in the preperimetric, borderline, and early OAG group were 2.7 ± 3.4 dB, 5.5 ± 2.6 dB, and 8.5 ± 3.4 dB respectively (all significantly above normal). The percentage of patients exceeding normal FDF-MD was 27.3 %, 60.7 %, and 87.9 % respectively. The age-adjusted FDF-mean defect (MD) of the G1X-protocol was not significantly correlated with refractive error, lens opacity, pupil size, or gender. Occurrence of ceiling effects (inability to detect targets at highest contrast) showed a high correlation with visual field losses (
R
= 0.72,
p
< 0.001). Local analysis indicates that SAP losses exceeding 5 dB could not be distinguished with the FDF technique.
Conclusion
The FDF stimulus was able to detect beginning glaucoma damage. Patients with SAP-MD values exceeding 5 dB should be monitored with conventional perimetry because of its larger dynamic range.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25511293</pmid><doi>10.1007/s00417-014-2887-9</doi><tpages>9</tpages></addata></record> |
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| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2015-03, Vol.253 (3), p.447-455 |
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| source | Springer Nature |
| subjects | Aged Female Glaucoma Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - physiopathology Humans Intraocular Pressure - physiology Male Medicine Medicine & Public Health Middle Aged Ophthalmology Optic Nerve Diseases - diagnosis Optic Nerve Diseases - physiopathology Tonometry, Ocular Vision Disorders - diagnosis Vision Disorders - physiopathology Visual Acuity - physiology Visual Field Tests - methods Visual Fields - physiology |
| title | Flicker-defined form perimetry in glaucoma patients |
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