Association of Myocardial T1-Mapping CMR With Hemodynamics and RV Performance in Pulmonary Hypertension

Abstract Early detection of right ventricular (RV) involvement in chronic pulmonary hypertension (PH) is essential due to prognostic implications. T1 mapping by cardiac magnetic resonance (CMR) has emerged as a noninvasive technique for extracellular volume fraction (ECV) quantification. We assessed...

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Published in:JACC. Cardiovascular imaging 2015, Vol.8 (1), p.76-82
Main Authors: García-Álvarez, Ana, MD, PhD, García-Lunar, Inés, MD, Pereda, Daniel, MD, Fernández-Jimenez, Rodrigo, MD, Sánchez-González, Javier, PhD, Mirelis, Jesús G., MD, PhD, Nuño-Ayala, Mario, PhD, Sánchez-Quintana, Damian, MD, Fernández-Friera, Leticia, MD, PhD, García-Ruiz, Jose M., MD, Pizarro, Gonzalo, MD, Agüero, Jaume, MD, Campelos, Paula, MD, Castellá, Manuel, MD, PhD, Sabaté, Manel, MD, PhD, Fuster, Valentin, MD, PhD, Sanz, Javier, MD, Ibañez, Borja, MD, PhD
Format: Article
Language:English
Subjects:
Animals
Cardiac Catheterization
Cardiovascular
Chronic Disease
equilibrium contrast
extracellular volume
Heart Ventricles - physiopathology
Hemodynamics
Hypertension, Pulmonary - pathology
Hypertension, Pulmonary - physiopathology
magnetic resonance
Magnetic Resonance Imaging
Male
Myocardium - pathology
native T1
pulmonary hypertension
Swine
T1 mapping
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Summary:Abstract Early detection of right ventricular (RV) involvement in chronic pulmonary hypertension (PH) is essential due to prognostic implications. T1 mapping by cardiac magnetic resonance (CMR) has emerged as a noninvasive technique for extracellular volume fraction (ECV) quantification. We assessed the association of myocardial native T1 time and equilibrium contrast ECV (Eq-ECV) at the RV insertion points with pulmonary hemodynamics and RV performance in an experimental model of chronic PH. Right heart catheterization followed by immediate CMR was performed on 38 pigs with chronic PH (generated by surgical pulmonary vein banding) and 6 sham-operated controls. Native T1 and Eq-ECV values at the RV insertion points were both significantly higher in banded animals than in controls and showed significant correlation with pulmonary hemodynamics, RV arterial coupling, and RV performance. Eq-ECV values also increased before overt RV systolic dysfunction, offering potential for the early detection of myocardial involvement in chronic PH.
ISSN:1936-878X
1876-7591
DOI:10.1016/j.jcmg.2014.08.012