Functional remediation for patients with bipolar II disorder: Improvement of functioning and subsyndromal symptoms

• Published in: European neuropsychopharmacology 2015-02, Vol.25 (2), p.257-264
• Main Authors: Solé, Brisa, Bonnin, C. Mar, Mayoral, María, Amann, Benedikt L, Torres, Imma, González-Pinto, Ana, Jimenez, Esther, Crespo, Jose Manuel, Colom, Francesc, Tabarés-Seisdedos, Rafael, Reinares, Maria, Ayuso-Mateos, Jose Luis, Soria, Sara, Garcia-Portilla, M. Paz, Ibañez, Ángela, Vieta, Eduard, Martinez-Aran, Anabel, Torrent, Carla
• Format: Article
• Language: English
• Subjects: Adult; Bipolar Disorder - therapy; Bipolar II disorder; Cognition; Cognitive functioning; Cognitive impairment; Cognitive remediation; Cognitive Therapy - methods; Female; Humans; Internal Medicine; Male; Psychiatric Status Rating Scales; Psychiatry; Single-Blind Method; Subsyndromic depressive symptoms; Treatment Outcome
• ISSN: 0924-977X; 1873-7862
• DOI: 10.1016/j.euroneuro.2014.05.010

Abstract Recently, Functional Remediation (FR) has proven to be effective in improving the functional outcome of euthymic bipolar patients. The aim of this study was to test the efficacy of the FR program in a subsample of euthymic bipolar II patients (BPII). A post-hoc analyses were undertaken using data of 53 BPII outpatients who had participated in a multicenter, rater-blind, randomized, controlled trial exploring the efficacy of FR ( n =17) as compared with a Psychoeducation group (PSY) ( n =19) and a treatment as usual control group (TAU n =17). The primary outcome variable was the functional improvement defined as the mean change in the Functioning Assessment Short Test (FAST) from baseline to endpoint after the intervention. Regarding the treatment effect, data reveal a significant functional improvement from baseline to endpoint, suggestive for an interaction between program pertinence and time (pre-post). Nevertheless, Tukey׳s post-hoc test only revealed a trend in favor of a better outcome for FR when compared to the other two groups. We also found an interaction between program pertinence and time when analysing the subdepressive symptoms, with BPII patients in FR showing a significant reduction when compared to the PSY group. Our results suggest that the FR appears to be effective in improving the overall functional outcome in BPII, as well as in reducing subdepressive symptoms.