Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles

•Au-CRC-TRC-NPs (170±20nm) showed RF-dependent curcumin release.•They have potential anti-cancer effects on breast cancer cells.•Improved PK/PD and tumor localization was observed in Au-CRC-TRC-NPs. The curcumin-encapsulated chitosan-graft-poly(N-vinyl caprolactam) nanoparticles containing gold nano...

Full description

Saved in:
Bibliographic Details
Published in:International journal of biological macromolecules 2015-03, Vol.74, p.249-262
Main Authors: Sanoj Rejinold, N., Thomas, Reju George, Muthiah, Muthunarayanan, Chennazhi, K.P., Manzoor, K., Park, In-Kyu, Jeong, Yong Yeon, Jayakumar, R.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - pharmacology
Apoptosis - drug effects
Caprolactam - chemistry
Cell Line, Tumor
Chitosan - chemistry
Chitosan-graft-PNVCL
Curcumin
Curcumin - administration & dosage
Curcumin - pharmacology
Disease Models, Animal
Drug Delivery Systems
Gold
Gold - chemistry
Humans
Hydrogen-Ion Concentration
Mice
Nanoparticles - chemistry
Neoplasms - pathology
Neoplasms - therapy
Particle Size
Pulsed Radiofrequency Treatment
RF therapy
Thermodynamics
Tissue Distribution
Tumor Burden - drug effects
Tumor Burden - radiation effects
Tumor localization
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Au-CRC-TRC-NPs (170±20nm) showed RF-dependent curcumin release.•They have potential anti-cancer effects on breast cancer cells.•Improved PK/PD and tumor localization was observed in Au-CRC-TRC-NPs. The curcumin-encapsulated chitosan-graft-poly(N-vinyl caprolactam) nanoparticles containing gold nanoparticles (Au-CRC-TRC-NPs) were developed by ionic cross-linking method. After “optimum RF exposure” at 40W for 5min, Au-CRC-TRC-NPs dissipated heat energy in the range of ∼42°C, the lower critical solution temperature (LCST) of chitosan-graft-poly(N-vinyl caprolactam), causing controlled curcumin release and apoptosis to cancer cells. Further, in vivo PK/PD studies on swiss albino mice revealed that Au-CRC-TRC-NPs could be sustained in circulation for a week with no harm to internal organs. The colon tumor localization studies revealed that Au-CRC-TRC-NPs were retained in tumor for a week. These results throw light on their feasibility as multi-responsive nanomedicine for RF-assisted cancer treatment modalities.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2014.11.044