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Multimodality treatment for advanced thymic carcinoma: outcomes of induction therapy followed by surgical resection in 16 cases at a single institution
Objective We reviewed our institutional experience with cases of multimodality treatment for advanced thymic carcinoma to determine patient outcomes and prognostic indicators. Methods Between 1998 and 2014, 16 patients with a Masaoka stage III or IV thymic carcinoma underwent surgical resection afte...
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| Published in: | General thoracic and cardiovascular surgery 2015-03, Vol.63 (3), p.159-163 |
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| container_title | General thoracic and cardiovascular surgery |
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| creator | Shintani, Yasushi Inoue, Masayoshi Kawamura, Tomohiro Funaki, Soichiro Minami, Masato Okumura, Meinoshin |
| description | Objective
We reviewed our institutional experience with cases of multimodality treatment for advanced thymic carcinoma to determine patient outcomes and prognostic indicators.
Methods
Between 1998 and 2014, 16 patients with a Masaoka stage III or IV thymic carcinoma underwent surgical resection after induction therapy at Osaka University Hospital. These were considered to have great vessel invasion or metastasis to the mediastinal or intrathoracic lymph nodes based on the preoperative workup findings, and received induction therapy.
Results
Complete tumor resection was achieved in 11 (69 %) after the induction therapy. Pathological findings revealed that 10 patients had Masaoka stage III disease, 1 had IVa, and 5 had IVb. The histological diagnosis was squamous cell carcinoma in 13, neuroendocrine carcinoma in 2, and undifferentiated carcinoma in 1. The 5-year survival rate for all patients was 71 %. Survival was significantly better in patients who underwent a complete resection (R0 disease) as compared to those with incompletely resected tumors (R1 or R2 disease).
Conclusions
Multimodality treatment offers encouraging results and complete resection provides high survival rate for patients with advanced thymic carcinoma. |
| doi_str_mv | 10.1007/s11748-014-0486-7 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660652030</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2918739419</sourcerecordid><originalsourceid>FETCH-LOGICAL-c532t-ce7cd5fb04d3258fddcfc6f2faca5ea3a1db2fc02476ac39c3fbe3928a5a631b3</originalsourceid><addsrcrecordid>eNp1kcuKFTEURYModtv6AU4k4MRJaR6VVJUzadQWWpzoOJzK45qmKrnm0VJf4u-aS7UtCI5yyFl7J7AQek7Ja0rI8CZTOvRjR2jfkX6U3fAAndNR8k4OlD-8n4k4Q09yviFEyJGKx-iMCU7p2E_n6NfnuhS_RgOLLxsuyUJZbSjYxYTB3ELQ1uDyfVu9xhqS9iGu8BbHWnRcbcbRYR9M1cXH0Dib4Li18LLEny04bzjXdPAaFpxstjvmA6ayteWWh4IBZx8Oi233ufhST8xT9MjBku2zu_MCffvw_uvlVXf95eOny3fXnRaclU7bQRvhZtIbzsTojNFOS8ccaBAWOFAzM6cJ6wcJmk-au9nyiY0gQHI68wv0au89pvij2lzU6rO2ywLBxpoVlZJIwQgnDX35D3oTawrtd4pNdBz41NOpUXSndIo5J-vUMfkV0qYoUSdraremmjV1sqaGlnlx11zn1Zr7xB9NDWA7kNsqHGz6-_T_W38DRtGmtg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918739419</pqid></control><display><type>article</type><title>Multimodality treatment for advanced thymic carcinoma: outcomes of induction therapy followed by surgical resection in 16 cases at a single institution</title><source>Springer Link</source><creator>Shintani, Yasushi ; Inoue, Masayoshi ; Kawamura, Tomohiro ; Funaki, Soichiro ; Minami, Masato ; Okumura, Meinoshin</creator><creatorcontrib>Shintani, Yasushi ; Inoue, Masayoshi ; Kawamura, Tomohiro ; Funaki, Soichiro ; Minami, Masato ; Okumura, Meinoshin</creatorcontrib><description>Objective
We reviewed our institutional experience with cases of multimodality treatment for advanced thymic carcinoma to determine patient outcomes and prognostic indicators.
Methods
Between 1998 and 2014, 16 patients with a Masaoka stage III or IV thymic carcinoma underwent surgical resection after induction therapy at Osaka University Hospital. These were considered to have great vessel invasion or metastasis to the mediastinal or intrathoracic lymph nodes based on the preoperative workup findings, and received induction therapy.
Results
Complete tumor resection was achieved in 11 (69 %) after the induction therapy. Pathological findings revealed that 10 patients had Masaoka stage III disease, 1 had IVa, and 5 had IVb. The histological diagnosis was squamous cell carcinoma in 13, neuroendocrine carcinoma in 2, and undifferentiated carcinoma in 1. The 5-year survival rate for all patients was 71 %. Survival was significantly better in patients who underwent a complete resection (R0 disease) as compared to those with incompletely resected tumors (R1 or R2 disease).
Conclusions
Multimodality treatment offers encouraging results and complete resection provides high survival rate for patients with advanced thymic carcinoma.</description><identifier>ISSN: 1863-6705</identifier><identifier>EISSN: 1863-6713</identifier><identifier>DOI: 10.1007/s11748-014-0486-7</identifier><identifier>PMID: 25311849</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Aged ; Cancer ; Carcinoma, Neuroendocrine - drug therapy ; Carcinoma, Neuroendocrine - pathology ; Carcinoma, Neuroendocrine - surgery ; Carcinoma, Neuroendocrine - therapy ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Carcinoma, Squamous Cell - therapy ; Cardiac Surgery ; Cardiology ; Chemotherapy ; Clinical outcomes ; Combined Modality Therapy ; Coronary vessels ; Disease ; Female ; Humans ; Induction therapy ; Lymphatic system ; Magnetic resonance imaging ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Neoadjuvant Therapy - methods ; Oncology ; Original Article ; Patients ; Pericardium ; Pulmonary arteries ; Radiation therapy ; Remission (Medicine) ; Surgical Oncology ; Survival Rate ; Thoracic Surgery ; Thymoma - drug therapy ; Thymoma - pathology ; Thymoma - surgery ; Thymoma - therapy ; Thymus Neoplasms - drug therapy ; Thymus Neoplasms - pathology ; Thymus Neoplasms - surgery ; Thymus Neoplasms - therapy ; Tomography ; Treatment Outcome ; Tumors ; Veins & arteries</subject><ispartof>General thoracic and cardiovascular surgery, 2015-03, Vol.63 (3), p.159-163</ispartof><rights>The Japanese Association for Thoracic Surgery 2014</rights><rights>The Japanese Association for Thoracic Surgery 2014.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-ce7cd5fb04d3258fddcfc6f2faca5ea3a1db2fc02476ac39c3fbe3928a5a631b3</citedby><cites>FETCH-LOGICAL-c532t-ce7cd5fb04d3258fddcfc6f2faca5ea3a1db2fc02476ac39c3fbe3928a5a631b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25311849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shintani, Yasushi</creatorcontrib><creatorcontrib>Inoue, Masayoshi</creatorcontrib><creatorcontrib>Kawamura, Tomohiro</creatorcontrib><creatorcontrib>Funaki, Soichiro</creatorcontrib><creatorcontrib>Minami, Masato</creatorcontrib><creatorcontrib>Okumura, Meinoshin</creatorcontrib><title>Multimodality treatment for advanced thymic carcinoma: outcomes of induction therapy followed by surgical resection in 16 cases at a single institution</title><title>General thoracic and cardiovascular surgery</title><addtitle>Gen Thorac Cardiovasc Surg</addtitle><addtitle>Gen Thorac Cardiovasc Surg</addtitle><description>Objective
We reviewed our institutional experience with cases of multimodality treatment for advanced thymic carcinoma to determine patient outcomes and prognostic indicators.
Methods
Between 1998 and 2014, 16 patients with a Masaoka stage III or IV thymic carcinoma underwent surgical resection after induction therapy at Osaka University Hospital. These were considered to have great vessel invasion or metastasis to the mediastinal or intrathoracic lymph nodes based on the preoperative workup findings, and received induction therapy.
Results
Complete tumor resection was achieved in 11 (69 %) after the induction therapy. Pathological findings revealed that 10 patients had Masaoka stage III disease, 1 had IVa, and 5 had IVb. The histological diagnosis was squamous cell carcinoma in 13, neuroendocrine carcinoma in 2, and undifferentiated carcinoma in 1. The 5-year survival rate for all patients was 71 %. Survival was significantly better in patients who underwent a complete resection (R0 disease) as compared to those with incompletely resected tumors (R1 or R2 disease).
Conclusions
Multimodality treatment offers encouraging results and complete resection provides high survival rate for patients with advanced thymic carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Cancer</subject><subject>Carcinoma, Neuroendocrine - drug therapy</subject><subject>Carcinoma, Neuroendocrine - pathology</subject><subject>Carcinoma, Neuroendocrine - surgery</subject><subject>Carcinoma, Neuroendocrine - therapy</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Combined Modality Therapy</subject><subject>Coronary vessels</subject><subject>Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Induction therapy</subject><subject>Lymphatic system</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy - methods</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Pericardium</subject><subject>Pulmonary arteries</subject><subject>Radiation therapy</subject><subject>Remission (Medicine)</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Thoracic Surgery</subject><subject>Thymoma - drug therapy</subject><subject>Thymoma - pathology</subject><subject>Thymoma - surgery</subject><subject>Thymoma - therapy</subject><subject>Thymus Neoplasms - drug therapy</subject><subject>Thymus Neoplasms - pathology</subject><subject>Thymus Neoplasms - surgery</subject><subject>Thymus Neoplasms - therapy</subject><subject>Tomography</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Veins & arteries</subject><issn>1863-6705</issn><issn>1863-6713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kcuKFTEURYModtv6AU4k4MRJaR6VVJUzadQWWpzoOJzK45qmKrnm0VJf4u-aS7UtCI5yyFl7J7AQek7Ja0rI8CZTOvRjR2jfkX6U3fAAndNR8k4OlD-8n4k4Q09yviFEyJGKx-iMCU7p2E_n6NfnuhS_RgOLLxsuyUJZbSjYxYTB3ELQ1uDyfVu9xhqS9iGu8BbHWnRcbcbRYR9M1cXH0Dib4Li18LLEny04bzjXdPAaFpxstjvmA6ayteWWh4IBZx8Oi233ufhST8xT9MjBku2zu_MCffvw_uvlVXf95eOny3fXnRaclU7bQRvhZtIbzsTojNFOS8ccaBAWOFAzM6cJ6wcJmk-au9nyiY0gQHI68wv0au89pvij2lzU6rO2ywLBxpoVlZJIwQgnDX35D3oTawrtd4pNdBz41NOpUXSndIo5J-vUMfkV0qYoUSdraremmjV1sqaGlnlx11zn1Zr7xB9NDWA7kNsqHGz6-_T_W38DRtGmtg</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Shintani, Yasushi</creator><creator>Inoue, Masayoshi</creator><creator>Kawamura, Tomohiro</creator><creator>Funaki, Soichiro</creator><creator>Minami, Masato</creator><creator>Okumura, Meinoshin</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Multimodality treatment for advanced thymic carcinoma: outcomes of induction therapy followed by surgical resection in 16 cases at a single institution</title><author>Shintani, Yasushi ; Inoue, Masayoshi ; Kawamura, Tomohiro ; Funaki, Soichiro ; Minami, Masato ; Okumura, Meinoshin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-ce7cd5fb04d3258fddcfc6f2faca5ea3a1db2fc02476ac39c3fbe3928a5a631b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cancer</topic><topic>Carcinoma, Neuroendocrine - drug therapy</topic><topic>Carcinoma, Neuroendocrine - pathology</topic><topic>Carcinoma, Neuroendocrine - surgery</topic><topic>Carcinoma, Neuroendocrine - therapy</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Chemotherapy</topic><topic>Clinical outcomes</topic><topic>Combined Modality Therapy</topic><topic>Coronary vessels</topic><topic>Disease</topic><topic>Female</topic><topic>Humans</topic><topic>Induction therapy</topic><topic>Lymphatic system</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoadjuvant Therapy - methods</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Pericardium</topic><topic>Pulmonary arteries</topic><topic>Radiation therapy</topic><topic>Remission (Medicine)</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Thoracic Surgery</topic><topic>Thymoma - drug therapy</topic><topic>Thymoma - pathology</topic><topic>Thymoma - surgery</topic><topic>Thymoma - therapy</topic><topic>Thymus Neoplasms - drug therapy</topic><topic>Thymus Neoplasms - pathology</topic><topic>Thymus Neoplasms - surgery</topic><topic>Thymus Neoplasms - therapy</topic><topic>Tomography</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shintani, Yasushi</creatorcontrib><creatorcontrib>Inoue, Masayoshi</creatorcontrib><creatorcontrib>Kawamura, Tomohiro</creatorcontrib><creatorcontrib>Funaki, Soichiro</creatorcontrib><creatorcontrib>Minami, Masato</creatorcontrib><creatorcontrib>Okumura, Meinoshin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>General thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shintani, Yasushi</au><au>Inoue, Masayoshi</au><au>Kawamura, Tomohiro</au><au>Funaki, Soichiro</au><au>Minami, Masato</au><au>Okumura, Meinoshin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multimodality treatment for advanced thymic carcinoma: outcomes of induction therapy followed by surgical resection in 16 cases at a single institution</atitle><jtitle>General thoracic and cardiovascular surgery</jtitle><stitle>Gen Thorac Cardiovasc Surg</stitle><addtitle>Gen Thorac Cardiovasc Surg</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>63</volume><issue>3</issue><spage>159</spage><epage>163</epage><pages>159-163</pages><issn>1863-6705</issn><eissn>1863-6713</eissn><abstract>Objective
We reviewed our institutional experience with cases of multimodality treatment for advanced thymic carcinoma to determine patient outcomes and prognostic indicators.
Methods
Between 1998 and 2014, 16 patients with a Masaoka stage III or IV thymic carcinoma underwent surgical resection after induction therapy at Osaka University Hospital. These were considered to have great vessel invasion or metastasis to the mediastinal or intrathoracic lymph nodes based on the preoperative workup findings, and received induction therapy.
Results
Complete tumor resection was achieved in 11 (69 %) after the induction therapy. Pathological findings revealed that 10 patients had Masaoka stage III disease, 1 had IVa, and 5 had IVb. The histological diagnosis was squamous cell carcinoma in 13, neuroendocrine carcinoma in 2, and undifferentiated carcinoma in 1. The 5-year survival rate for all patients was 71 %. Survival was significantly better in patients who underwent a complete resection (R0 disease) as compared to those with incompletely resected tumors (R1 or R2 disease).
Conclusions
Multimodality treatment offers encouraging results and complete resection provides high survival rate for patients with advanced thymic carcinoma.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>25311849</pmid><doi>10.1007/s11748-014-0486-7</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Cancer Carcinoma, Neuroendocrine - drug therapy Carcinoma, Neuroendocrine - pathology Carcinoma, Neuroendocrine - surgery Carcinoma, Neuroendocrine - therapy Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Carcinoma, Squamous Cell - therapy Cardiac Surgery Cardiology Chemotherapy Clinical outcomes Combined Modality Therapy Coronary vessels Disease Female Humans Induction therapy Lymphatic system Magnetic resonance imaging Male Medical prognosis Medicine Medicine & Public Health Metastasis Middle Aged Neoadjuvant Therapy - methods Oncology Original Article Patients Pericardium Pulmonary arteries Radiation therapy Remission (Medicine) Surgical Oncology Survival Rate Thoracic Surgery Thymoma - drug therapy Thymoma - pathology Thymoma - surgery Thymoma - therapy Thymus Neoplasms - drug therapy Thymus Neoplasms - pathology Thymus Neoplasms - surgery Thymus Neoplasms - therapy Tomography Treatment Outcome Tumors Veins & arteries |
| title | Multimodality treatment for advanced thymic carcinoma: outcomes of induction therapy followed by surgical resection in 16 cases at a single institution |
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