Assessing of oxidative stress related parameters in diabetes mellitus type 2: cause excessive damaging to DNA and enhanced homocysteine in diabetic patients

• Published in: Pakistan journal of pharmaceutical sciences 2015-03, Vol.28 (2), p.483-491
• Main Authors: Bukhari, Shazia Anwer, Naqvi, Syed Ali Raza, Nagra, Saeed Ahmad, Anjum, Fauzia, Javed, Sadia, Farooq, Muhammad
• Format: Article
• Language: English
• Subjects: Analysis; Antioxidants - analysis; Diabetes; Diabetes Mellitus, Type 2 - metabolism; DNA Damage; Female; Genetic aspects; Health aspects; Homocysteine; Homocysteine - blood; Humans; Lipid Peroxidation; Male; Oxidative Stress; Risk factors
• ISSN: 1011-601X

Oxidative stress and reactive oxygen species (ROS) have been documented subsist to the pathogenesis of many diseases including diabetes mellitus. The strength of both parameters could be estimated by measuring oxidative stress marker thiobarbituric acid reactive substances (TBARS), its related parameters and the antioxidants glutathione peroxidase and superoxide dismutase (SOD) in plasma of DM patients. Lipid peroxidation was measured as TBARS and presented as malondialdehyde, total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (Tg), the antioxidants (vitamin A (β-carotene), vitamin E, vitamin C, glutathione peroxidase (GPx) and superoxide dismutase) levels. The results showed that these parameters, commonly, were declined appreciably in diabetic individuals as compared to the healthy individuals. In most cases, age and gender were appeared to involve in having greater values of diabetes marker. Further, increased level of lipid peroxidation and random behaviour of antioxidant potential also associated with Diabetes. For that reason these biomarkers might be of great important to diagnosis DNA damages of diabetic patients.