Organic solvent and temperature-enhanced ion chromatography-high resolution mass spectrometry for the determination of low molecular weight organic and inorganic anions

[Display omitted] •IC selectivity at high contents of organic solvent in eluent and elevated temperature is studied.•Solvent-enhanced IC coupled to high resolution MS is beneficial for sensitive detection of ions.•The first application of IC-HRMS to the detection of low explosives in fingermarks is...

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Bibliographic Details
Published in:Analytica chimica acta 2015-03, Vol.865, p.83-91
Main Authors: Gilchrist, Elizabeth S., Nesterenko, Pavel N., Smith, Norman W., Barron, Leon P.
Format: Article
Language:English
Subjects:
Acetonitriles - chemistry
Anions
Anions - analysis
Chromatography, High Pressure Liquid
High resolution mass spectrometry
Humans
Ion chromatography
Mass Spectrometry
Methanol - chemistry
Molecular Weight
Nitrates - analysis
Organic solvent
Perchlorates - analysis
Phthalic Acids - analysis
Solvents - chemistry
Temperature
Thiocyanates - analysis
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Summary:[Display omitted] •IC selectivity at high contents of organic solvent in eluent and elevated temperature is studied.•Solvent-enhanced IC coupled to high resolution MS is beneficial for sensitive detection of ions.•The first application of IC-HRMS to the detection of low explosives in fingermarks is shown. There has recently been increased interest in coupling ion chromatography (IC) to high resolution mass spectrometry (HRMS) to enable highly sensitive and selective analysis. Herein, the first comprehensive study focusing on the direct coupling of suppressed IC to HRMS without the need for post-suppressor organic solvent modification is presented. Chromatographic selectivity and added HRMS sensitivity offered by organic solvent-modified IC eluents on a modern hyper-crosslinked polymeric anion-exchange resin (IonPac AS18) are shown using isocratic eluents containing 5–50mM hydroxide with 0–80% methanol or acetonitrile for a range of low molecular weight anions (
ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2015.01.031