Effects of resveratrol on doxorubicin induced testicular damage in rats

The purpose of this study was to evaluate the likely protective effect of resveratrol (RES) on doxorubicin (DOX) induced testicular damage. Rats were divided into five groups: control, RES, dimethyl sulfoxide (DMSO), DOX and DOX+RES. At the end of treatment, the rats were sacrificed. Plasma testoste...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2015-03, Vol.67 (3), p.229-235
Main Authors: Türedi, Sibel, Yuluğ, Esin, Alver, Ahmet, Kutlu, Ömer, Kahraman, Cemil
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - toxicity
Antioxidants - pharmacology
Apoptosis
Apoptosis - drug effects
Disease Models, Animal
Doxorubicin
Doxorubicin - toxicity
In Situ Nick-End Labeling
Infertility
Male
Rats
Rats, Sprague-Dawley
Resveratrol
Sperm Motility - drug effects
Spermatozoa - drug effects
Spermatozoa - pathology
Stilbenes - pharmacology
Testicular toxicity
Testis - drug effects
Testis - pathology
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Summary:The purpose of this study was to evaluate the likely protective effect of resveratrol (RES) on doxorubicin (DOX) induced testicular damage. Rats were divided into five groups: control, RES, dimethyl sulfoxide (DMSO), DOX and DOX+RES. At the end of treatment, the rats were sacrificed. Plasma testosterone levels, oxidative status, epididymal sperm parameters and testicular apoptosis were evaluated. MDA levels, GP-x and GSH activities were higher in the DOX group than in the control group. MDA levels were lower in the DOX+RES group than in the DOX group. The DOX group exhibited a significant decrease in plasma testosterone levels, sperm concentration and motility, and a significant increase in abnormal sperm rate and TUNEL (+) cells in the testis. A significant increase was observed in plasma testosterone levels and sperm concentration and motility, and a significant decrease in the abnormal sperm rate and TUNEL (+) cells in the DOX+RES group compared to the DOX group. A marked improvement in severe degenerative alterations in the germinative epithelium was also observed following treatment with RES. In conclusion, RES makes a positive contribution to fertility by exhibiting anti-apoptotic and antiperoxidative effects against DOX-induced testicular damage.
ISSN:0940-2993
1618-1433
DOI:10.1016/j.etp.2014.12.002