Secretory proteins without a transport signal are retained in secretory granules during maturation in rat parotid acinar cells

Highlights • The acinar cells of parotid glands from isoproterenol-treated rats were isolated. • The tracer uptake in immature secretory granules and during secretion was assessed. • The intracellular localization of the tracer was confirmed by electron microscopy. • The results show that the tracer...

Full description

Saved in:
Bibliographic Details
Published in:Archives of oral biology 2015-04, Vol.60 (4), p.642-649
Main Authors: Katsumata-Kato, Osamu, Yokoyama, Megumi, Matsuki-Fukushima, Miwako, Narita, Takanori, Sugiya, Hiroshi, Fujita-Yoshigaki, Junko
Format: Article
Language:English
Subjects:
Acinar Cells - metabolism
Advanced Basic Science
Amylases - metabolism
Animals
Cells, Cultured
Cytoplasmic Granules - metabolism
Dentistry
Endocytosis
Granule maturation
Isoproterenol - pharmacology
Microscopy, Confocal
Microscopy, Electron
Parotid gland
Parotid Gland - metabolism
Rats
Salivary gland
Secretory granules
Secretory vesicles
Secretory Vesicles - metabolism
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • The acinar cells of parotid glands from isoproterenol-treated rats were isolated. • The tracer uptake in immature secretory granules and during secretion was assessed. • The intracellular localization of the tracer was confirmed by electron microscopy. • The results show that the tracer was retained in the granules after maturation. • We conclude that secretory proteins do not require a signal for their retention.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2015.01.006