Understanding history, and not repeating it. Neuroprotection for acute ischemic stroke: From review to preview

Highlights • Prior studies of neuroprotective therapy for stroke were limited by technology and design. • We review molecular therapeutic targets in prior neuroprotective studies. • Through our review, vital principles emerge to explain lack of efficacy in prior trials. • Our study provides insight...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2015-02, Vol.129, p.1-9
Main Authors: Grupke, Stephen, Hall, Jason, Dobbs, Michael, Bix, Gregory J, Fraser, Justin F
Format: Article
Language:English
Subjects:
Acute stroke
Angiography
Animals
Apoptosis
Apoptosis - drug effects
Apoptosis - physiology
Brain ischemia
Brain Ischemia - therapy
Clinical trials
Cytotoxicity
Drug trials
Fibrinolytic Agents - therapeutic use
Free radicals
Human subjects
Humans
Ischemia
Metabolism
Metabolites
Mortality
Neurology
Neurons
Neuroprotection
Neuroprotective Agents - therapeutic use
Neurosurgery
Rodents
Stroke
Stroke - therapy
Studies
Thrombolytic Therapy
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Summary:Highlights • Prior studies of neuroprotective therapy for stroke were limited by technology and design. • We review molecular therapeutic targets in prior neuroprotective studies. • Through our review, vital principles emerge to explain lack of efficacy in prior trials. • Our study provides insight to direct future efforts in stroke neuroprotective therapy.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2014.11.013