Hyperuricemia, Gout, and Cardiovascular Disease: An Update

Across the globe, both gout and hyperuricemia have become increasingly common over the last few decades. The burden of gouty disease is made heavier by its association with several comorbid conditions, including hypertension, cardiovascular disease, and chronic kidney disease. Accruing evidence from...

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Bibliographic Details
Published in:Current rheumatology reports 2015-03, Vol.17 (3), p.13-13, Article 13
Main Author: Abeles, Aryeh M.
Format: Article
Language:English
Subjects:
Cardiovascular Diseases - etiology
Crystal Arthritis (MH Pillinger and S Krasnokutsky
Gout - complications
Humans
Hyperuricemia - complications
Medicine
Medicine & Public Health
Rheumatology
Risk Factors
Section Editors
Topical Collection on Crystal Arthritis
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Summary:Across the globe, both gout and hyperuricemia have become increasingly common over the last few decades. The burden of gouty disease is made heavier by its association with several comorbid conditions, including hypertension, cardiovascular disease, and chronic kidney disease. Accruing evidence from prospective studies suggests that gout is an independent risk factor for developing cardiovascular disease and for higher cardiovascular mortality. While asymptomatic hyperuricemia does not seem to be an independent risk factor for cardiovascular disease, increasing data implicates hyperuricemia as a risk factor for developing incidental hypertension. Important questions that remain unanswered include whether addressing asymptomatic hyperuricemia forestalls the onset of hypertension, and whether treating gout with urate-lowering agents improves cardiovascular outcomes. This article reviews the most recent data regarding the relationship between hyperuricemia, gout, hypertension, and cardiovascular disease, as well as emerging evidence as to whether treatment of hyperuricemia and gout improves cardiovascular outcomes.
ISSN:1523-3774
1534-6307
DOI:10.1007/s11926-015-0495-2