Severe post‐transplant lymphoproliferative disorder after living donor liver transplantation

• Published in: Hepatology research 2015-03, Vol.45 (3), p.356-362
• Main Authors: Kuramitsu, Kaori, Fukumoto, Takumi, Fukushima, Kenji, Iwasaki, Takeshi, Tominaga, Masahiro, Matsui, Toshimitsu, Kawakami, Fumi, Itoh, Tomoo, Ku, Yonson
• Format: Article
• Language: English
• Subjects: chemotherapy; Epstein–Barr virus; liver transplantation; post‐transplant lymphoproliferative disorder
• ISSN: 1386-6346; 1872-034X
• DOI: 10.1111/hepr.12345

Post‐transplant lymphoproliferative disorder (PTLD) is a well‐known complication after transplantation. A living donor liver transplantation was performed on a 31‐year‐old man for fulminant hepatitis. He again developed liver dysfunction after 7 months. He was diagnosed as having acute cellular rejection and the steroid pulse therapy introduced resulted in little improvement. He gradually developed a high fever and right axillary lymphadenopathy appeared. Chest computed tomography (CT) was performed revealing small lung nodules and axillary lymphadenopathy. Because his serological status for Epstein–Barr virus was positive, PTLD was highly suspected and immunosuppression treatment was withdrawn with little improvement. One week later, he developed tachycardia. Chest CT was re‐performed revealing an infiltration to the left cardiac chamber. For diagnosis, axillary lymph node biopsy was performed and during the procedure, he developed ventricular tachycardia (VT). Immunohistological staining revealed PTLD of T lymphocytes, and chemotherapy was introduced on the same day he developed VT. After two cycles of tetrahydropyranyl, adriamycin, cyclophosphamide, vincristine, prednisolone and etoposide treatment, he completely recovered. This is a first case report of severe PTLD with VT, and our case implies the feasibility of chemotherapy after the appearance of dissemination symptoms.