Polygonum cuspidatum extracts as bioactive antioxidaion, anti-tyrosinase, immune stimulation and anticancer agents

In our study, it was applied for the technology of supercritical fluid carbon dioxide extraction to achieve biological constitutes from a Taiwan native plant, Polygonum cuspidatum. We developed bioactive effects of P. cuspidatum extracts via multiple examinations that established bio-purposes at a r...

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Bibliographic Details
Published in:Journal of bioscience and bioengineering 2015-04, Vol.119 (4), p.464-469
Main Authors: Lee, Chih-Chen, Chen, Yen-Ting, Chiu, Chien-Chih, Liao, Wei-Ting, Liu, Yung-Chuan, David Wang, Hui-Min
Format: Article
Language:English
Subjects:
Agaricales - enzymology
Anti-cancer
Anti-tyrosinase
Antineoplastic Agents - pharmacology
Antioxidant
Cell Line
Cell Proliferation - drug effects
Chromatography, Supercritical Fluid
Fallopia japonica - chemistry
Humans
Immune
Immunity - drug effects
Immunity - immunology
Macrophages - drug effects
Macrophages - immunology
Melanins - biosynthesis
Melanoma - drug therapy
Melanoma - pathology
Monophenol Monooxygenase - antagonists & inhibitors
Monophenol Monooxygenase - metabolism
Oxidation-Reduction - drug effects
Plant Extracts - pharmacology
Polygonum cuspidatum
Supercritical fluid carbon dioxide extraction
Taiwan
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Summary:In our study, it was applied for the technology of supercritical fluid carbon dioxide extraction to achieve biological constitutes from a Taiwan native plant, Polygonum cuspidatum. We developed bioactive effects of P. cuspidatum extracts via multiple examinations that established bio-purposes at a range of dosage ranges. The research of P. cuspidatum extracts indicated that they possessed anti-oxidative properties on radical-scavenging abilities, reducing activities and metal chelating powers in dose-dependant manners. The extracts also had minor in vitro mushroom tyrosinase suppression and decreased cellular tyrosinase activities and melanin production in B16-F10 cells. Immunologically, P. cuspidatum extracts enhanced the release of tumor necrosis factor α (TNF-α) induced by THP-1 macrophage cell line. In addition, the cell proliferation showed anti-proliferation in dose-dependent manner on human skin melanoma cells, A375 and A375.S2, of the extracts suggesting biological constitutes employed the anti-cancer possessions. This is the first statement presenting bioactivities on P. cuspidatum extracts including anti-oxidation, immune stimulation, anti-tyrosinase and anti-melanoma as far as we know.
ISSN:1389-1723
1347-4421
DOI:10.1016/j.jbiosc.2014.09.008