Backbone and stereospecific (13)C methyl Ile (δ1), Leu and Val side-chain chemical shift assignments of Crc

Carbon catabolite repression (CCR) allows bacteria to selectively assimilate a preferred compound among a mixture of several potential carbon sources, thus boosting growth and economizing the cost of adaptability to variable nutrients in the environment. The RNA-binding catabolite repression control...

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Bibliographic Details
Published in:Biomolecular NMR assignments 2015-04, Vol.9 (1), p.75-79
Main Authors: Sharma, Rakhi, Sahu, Bhubanananda, Ray, Malay K, Deshmukh, Mandar V
Format: Article
Language:English
Subjects:
Bacterial Proteins - chemistry
Isoleucine
Leucine
Nuclear Magnetic Resonance, Biomolecular
Pseudomonas syringae
Repressor Proteins - chemistry
Stereoisomerism
Valine
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Summary:Carbon catabolite repression (CCR) allows bacteria to selectively assimilate a preferred compound among a mixture of several potential carbon sources, thus boosting growth and economizing the cost of adaptability to variable nutrients in the environment. The RNA-binding catabolite repression control (Crc) protein acts as a global post-transcriptional regulator of CCR in Pseudomonas species. Crc triggers repression by inhibiting the expression of genes involved in transport and catabolism of non-preferred substrates, thus indirectly favoring assimilation of preferred one. We report here a nearly complete backbone and stereospecific (13)C methyl side-chain chemical shift assignments of Ile (δ1), Leu and Val of Crc (~ 31 kDa) from Pseudomonas syringae Lz4W.
ISSN:1874-270X
DOI:10.1007/s12104-014-9548-0