Clinical Outcome of Renal Artery Stenting for Hypertension and Chronic Kidney Disease up to 12 Months in the J-RAS Study: Prospective, Single-Arm, Multicenter Clinical Study

• Published in: Circulation Journal 2015/01/23, Vol.79(2), pp.351-359
• Main Authors: Fujihara, Masahiko, Yokoi, Yoshiaki, Abe, Takaaki, Soga, Yoshimitsu, Yamashita, Takehiro, Miyashita, Yusuke, Nakamura, Masato, Yokoi, Hiroyoshi, Ito, Sadayoshi, on behalf of the J-RAS Study Investigators
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Asian Continental Ancestry Group; Atherosclerosis - physiopathology; Atherosclerosis - surgery; Atherosclerotic renal artery stenosis; Blood Pressure; Chronic kidney disease; Glomerular Filtration Rate; Humans; Hypertension; Hypertension - physiopathology; Hypertension - surgery; Japan; Middle Aged; Prospective Studies; Renal Artery - physiopathology; Renal Artery - surgery; Renal artery stenting; Renal Insufficiency, Chronic - physiopathology; Renal Insufficiency, Chronic - surgery; Stents
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.CJ-14-0908

Background:Atherosclerotic renal artery stenosis (ARAS) causes renovascular hypertension (HTN) and impairs renal function, leading to chronic kidney disease (CKD). The J-RAS study was a prospective, multicenter study to assess the clinical outcome of renal artery stenting for up to 1 year in Japanese patients with ARAS.Methods and Results:One hundred and forty-nine patients were enrolled between November 2010 and January 2013. The patients were classified into an HTN (n=121) group and a CKD (n=108) group in the primary analysis. The primary efficacy endpoints were change in blood pressure for the HTN group and change in estimated glomerular filtration rate (eGFR) for the CKD group at 1 months. The primary safety endpoint was freedom from major cardiovascular or renal events at 12 months. In the HTN group, the mean systolic blood pressure (SBP) significantly decreased from 161.6±21 mmHg at baseline to 137.0±21 mmHg (P