Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats

• Published in: Revista brasileira de anestesiologia 2015-03, Vol.65 (2), p.124-129
• Main Authors: Moura, Lanucha Fidelis da Luz, Vidor, Silvana Bellini, Trindade, Anelise Bonilla, Mörschbächer, Priscilla Domingues, Oleskovicz, Nilson, Contesini, Emerson Antonio
• Format: Article
• Language: Portuguese
• ISSN: 1806-907X
• DOI: 10.1016/j.bjan.2013.10.018

Evaluate the antinociceptive effects of subarachnoid meloxicam on the mechanical hypernociception induced by carrageenan in rats. Randomized controlled trial. Eighteen adult male Wistar rats underwent a cannula implantation into the subarachnoid space and were randomly divided into two groups: Group I (GI) received saline solution 5μL, while Group II (GII) received meloxicam 30mg. The mechanical hypernociception was induced by intraplantar injection of carrageenan and evaluated using a digital analgesymeter every 30minutes during a 4 hour period. The results were recorded as the Δ withdrawal threshold (in g), calculated by subtracting the measurement value after The Δ withdrawal threshold mean values were lower in the group of patients treated with meloxicam over all time points between 45 and 165minutes, however, there was no statistical significance, (p=0.835) for this difference. Subarachnoid meloxicam at a dose of 30μg.animal(-1) did not suppress the mechanical hypernociception in a model of inflammatory pain induced by intraplantar administration of carrageenan in rats. The data suggest that other dosages should be investigated the drug effect is discarded.