Does the primary site of colorectal cancer impact outcomes for patients with metastatic disease?

BACKGROUND Previous reports have described differences in biology and outcome for colorectal cancer based on whether the primary is right or left sided. Further division by right, left, and rectum or even exact primary site has also been explored. Possible differences in response to biological agent...

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Bibliographic Details
Published in:Cancer 2015-03, Vol.121 (6), p.830-835
Main Authors: Price, Timothy J., Beeke, Carol, Ullah, Shahid, Padbury, Robert, Maddern, Guy, Roder, David, Townsend, Amanda R., Moore, James, Roy, Amitesh, Tomita, Yoko, Karapetis, Christos
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
colorectal cancer
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Female
Humans
Male
Middle Aged
Neoplasm Metastasis
primary site
registry
South Australia - epidemiology
survival
Survival Analysis
Treatment Outcome
Young Adult
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Summary:BACKGROUND Previous reports have described differences in biology and outcome for colorectal cancer based on whether the primary is right or left sided. Further division by right, left, and rectum or even exact primary site has also been explored. Possible differences in response to biological agents have also been reported based on side of primary lesion. METHODS We explored the South Australian registry for metastatic colorectal cancer to assess if there were any differences in patient characteristics, prognostic markers, and treatment received and outcomes based on whether the primary was right or left sided. We also explored if differences exist based on left colon and rectum and by exact primary site. RESULTS Two thousand nine hundred seventy‐two patients were analyzed. Thirty‐five percent had a right‐sided primary. The median overall survival for the entire group right versus left was 9.6 versus 20.3 months (P 
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.29129