Markers of Myocardial Damage in Children of the First Year of Life with Congenital Heart Disease in the Early Period after Surgery with Cardioplegic Anoxia

We measured the level of cardiac markers (high-sensitivity troponin T and MB fraction of creatine kinase) in children of the first year of life with congenital heart disease in the perioperative period. After cardiac surgery, plasma levels of the above markers exceed the reference limits in the exam...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-02, Vol.158 (4), p.421-424
Main Authors: Kozar, E. F., Plyushch, M. G., Popov, A. E., Kulaga, O. I., Movsesyan, R. R., Samsonova, N. N., Bokeriya, L. A.
Format: Article
Language:English
Subjects:
Area Under Curve
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Cell Biology
Congenital heart disease
Creatine
Creatine kinase
Creatine Kinase, MB Form - blood
Diagnosis
Genetic disorders
Heart Arrest, Induced - adverse effects
Heart Defects, Congenital - blood
Heart Defects, Congenital - complications
Heart Defects, Congenital - surgery
Heart diseases
Humans
Hypoxia - etiology
Hypoxia - pathology
Infant
Internal Medicine
Ischemia
Laboratory Medicine
Myocardial Ischemia - diagnosis
Myocardial Ischemia - etiology
Pathology
ROC Curve
Troponin T - blood
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Summary:We measured the level of cardiac markers (high-sensitivity troponin T and MB fraction of creatine kinase) in children of the first year of life with congenital heart disease in the perioperative period. After cardiac surgery, plasma levels of the above markers exceed the reference limits in the examined children. The diagnosis of myocardial ischemia using biochemical markers in the postoperative period is possible only by dynamic monitoring of the cardiac marker level. The preoperative concentration of high-sensitivity troponin T in children of the first year of life with congenital heart disease can be regarded as a predictor of postoperative complications.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-2776-1