Proton beam therapy combined with concurrent chemotherapy for esophageal cancer

The aim of the present study was to evaluate the outcomes of proton beam therapy (PBT) concurrently combined with chemotherapy consisting of cisplatin and 5-fluorouracil for esophageal cancer. Forty consecutive patients (stage I in 16 patients, II in 9 and III in 15) treated between 2008 and 2012 we...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2015-03, Vol.35 (3), p.1757-1762
Main Authors: Ishikawa, Hitoshi, Hashimoto, Takayuki, Moriwaki, Toshikazu, Hyodo, Ichinosuke, Hisakura, Katsuji, Terashima, Hideo, Ohkohchi, Nobuhiro, Ohno, Toshiki, Makishima, Hirokazu, Mizumoto, Masashi, Ohnishi, Kayoko, Okumura, Toshiyuki, Sakurai, Hideyuki
Format: Article
Language:English
Subjects:
Aged
Chemoradiotherapy
Esophageal Neoplasms - therapy
Female
Humans
Male
Middle Aged
Morbidity
Neoplasm Recurrence, Local
Proton Therapy
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the present study was to evaluate the outcomes of proton beam therapy (PBT) concurrently combined with chemotherapy consisting of cisplatin and 5-fluorouracil for esophageal cancer. Forty consecutive patients (stage I in 16 patients, II in 9 and III in 15) treated between 2008 and 2012 were evaluated. A total dose of 60 Gray equivalents (GyE) in 30 fractions was delivered, and an additional boost of 4-10 GyE was given when residual tumors were suspected. The median follow-up time was 24 months (range=7-66 months). No cardio-pulmonary toxicities of grade 3 or higher were observed. Recurrences were observed in 16 patients, and the 2-year rates of disease-specific survival and locoregional control were 77% and 66%, respectively. Irrespective of the small sample size and short follow-up time of the study, proton beam therapy combined with chemo therapy seems to be feasible for esophageal cancer.
ISSN:1791-7530