Human herpes simplex virus: Life cycle and development of inhibitors

WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2014-12, Vol.79 (13), p.1635-1652
Main Authors: Kukhanova, M. K., Korovina, A. N., Kochetkov, S. N.
Format: Article
Language:English
Subjects:
Antiviral Agents - chemistry
Antiviral Agents - therapeutic use
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Development strategies
Drug resistance
Drug Resistance, Viral
Drug therapy
Genome, Viral
Health aspects
Herpes simplex virus
Herpes simplex virus 1
Herpes viruses
Herpesviridae
Herpesvirus
Herpesvirus 1, Human - drug effects
Herpesvirus 1, Human - genetics
Herpesvirus 1, Human - physiology
Host-virus relationships
Human immunodeficiency virus
Human populations
Humans
Life cycles
Life Sciences
Microbiology
Mutation
Prevention
Review
Skin diseases
Virion - ultrastructure
Virus Replication
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Summary:WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297914130124