Respiratory Proteomics: From Descriptive Studies to Personalized Medicine

Respiratory diseases are highly prevalent and affect humankind worldwide, causing extensive morbidity and mortality with the environment playing an important role. Given the complex structure of the airways, sophisticated tools are required for early diagnosis; initial symptoms are nonspecific, and...

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Bibliographic Details
Published in:Journal of proteome research 2015-01, Vol.14 (1), p.38-50
Main Authors: Teran, Luis M, Montes-Vizuet, Rosalia, Li, Xinping, Franz, Thomas
Format: Article
Language:English
Subjects:
Animals
Biomarkers - metabolism
Humans
Lung Diseases - metabolism
Lung Diseases - therapy
Precision Medicine
Proteome - metabolism
Proteomics
Rhinitis - metabolism
Rhinitis - therapy
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Summary:Respiratory diseases are highly prevalent and affect humankind worldwide, causing extensive morbidity and mortality with the environment playing an important role. Given the complex structure of the airways, sophisticated tools are required for early diagnosis; initial symptoms are nonspecific, and the clinical diagnosis is made frequently late. Over the past few years, proteomics has made high technological progress in mass-spectrometry-based protein identification and has allowed us to gain new insights into disease mechanisms and identify potential novel therapeutic targets. This review will highlight the contributions of proteomics toward the understanding of the respiratory proteome listing potential biomarkers and its potential application to the clinic. We also outline the contributions of proteomics to creating a personalized approach in respiratory medicine.
ISSN:1535-3893
1535-3907
DOI:10.1021/pr500935s