Research progress in signalling pathway in diabetic nephropathy

Summary Diabetic nephropathy, a lethal diabetic complication, is a leading cause of end‐stage renal disease, which is pathologically characterized by thickened tubular basal and glomerular membranes, accumulated extracellular matrix, and progressive mesangial hypertrophy. Growing evidence indicates...

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Bibliographic Details
Published in:Diabetes/metabolism research and reviews 2015-03, Vol.31 (3), p.221-233
Main Authors: Ni, Wei-Jian, Tang, Li-Qin, Wei, Wei
Format: Article
Language:English
Subjects:
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - pathology
Diabetic Nephropathies - prevention & control
diabetic nephropathy
glomerular mesangial cell
Humans
Inflammation
Oxidative Stress
podocyte
renal fibrosis
Signal Transduction
signalling pathway
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Summary:Summary Diabetic nephropathy, a lethal diabetic complication, is a leading cause of end‐stage renal disease, which is pathologically characterized by thickened tubular basal and glomerular membranes, accumulated extracellular matrix, and progressive mesangial hypertrophy. Growing evidence indicates that diabetic nephropathy is induced by multiple conditions, such as glucose metabolism disorder, oxidative stress, numerous inflammatory factors and cytokines, and haemodynamic changes that lead to the occurrence and development of diabetic nephropathy based on genetic susceptibility. A variety of abnormalities in the signalling pathway may interact to produce these pathologic processes. Research has aimed to highlight the signalling pathway mechanisms that lead to diabetic nephropathy so that preventative strategies and effective therapies might be developed. In this review, important pathways that appear to be involved in driving these processes are discussed. Copyright © 2014 John Wiley & Sons, Ltd.
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.2568