High pulse pressure is not associated with abnormal activation of the renin–angiotensin–aldosterone system in repaired aortic coarctation

We investigated the relationship between pulse pressure (PP)—a surrogate marker of arterial stiffness—and activity of the renin–angiotensin–aldosterone system (RAAS) in adult patients with repaired coarctation and normal left ventricular (LV) function. A total of 114 patients (44 (26–74) years, 13 (...

Full description

Saved in:
Bibliographic Details
Published in:Journal of human hypertension 2015-04, Vol.29 (4), p.268-273
Main Authors: Pedersen, T A L, Pedersen, E B, Munk, K, Hjortdal, V E, Emmertsen, K, Andersen, N H
Format: Article
Language:English
Subjects:
59/57
692/699/75/1539
9/25
Adult
Aged
Aldosterone
Angiotensin
Antihypertensive Agents - therapeutic use
Antihypertensives
Aorta
Aorta, Thoracic - physiopathology
Aorta, Thoracic - surgery
Aortic coarctation
Aortic Coarctation - complications
Aortic Coarctation - physiopathology
Aortic Coarctation - surgery
Arterial Pressure - drug effects
Biomarkers - blood
Blood pressure
Care and treatment
Case-Control Studies
Development and progression
Echocardiography
Epidemiology
Female
Health Administration
Health aspects
Heart
Humans
Hypertension
Hypertension - diagnosis
Hypertension - drug therapy
Hypertension - etiology
Hypertension - physiopathology
Male
Medicine
Medicine & Public Health
Middle Aged
original-article
Public Health
Recurrence
Renin
Renin-angiotensin system
Renin-Angiotensin System - drug effects
Risk Factors
Thorax
Time Factors
Treatment Outcome
Vascular Stiffness
Vasoactive agents
Ventricle
Ventricular Function, Left
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the relationship between pulse pressure (PP)—a surrogate marker of arterial stiffness—and activity of the renin–angiotensin–aldosterone system (RAAS) in adult patients with repaired coarctation and normal left ventricular (LV) function. A total of 114 patients (44 (26–74) years, 13 (0.1–40) years at repair) and 20 healthy controls were examined with 24-h ambulatory blood pressure monitoring, echocardiography, vasoactive hormone levels and magnetic resonance of the thoracic aorta. Forty-one patients (36%) were taking antihypertensives (28 RAAS inhibitors). Fifty-one had mean 24-h blood pressures >130/80 mm Hg. Hypertension was not associated with age at repair ( P =0.257). Patients had higher PP and LV mass compared with controls (52±11 vs 45±5 mm Hg and 221±71 vs 154±55 g, respectively; both P
ISSN:0950-9240
1476-5527
DOI:10.1038/jhh.2014.75