Weaning Gives β Cells License to Regenerate

Pancreatic beta cell proliferation is high at birth and then rapidly declines. In this issue of Developmental Cell, Stolovich-Rain et al. (2015) show that β cells’ capacity to increase proliferation in response to injury is unexpectedly not acquired until after weaning-related nutritional changes tr...

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Bibliographic Details
Published in:Developmental cell 2015-03, Vol.32 (5), p.531-532
Main Authors: Rovira, Meritxell, Ferrer, Jorge
Format: Article
Language:English
Subjects:
Animals
Biomarkers - metabolism
Cell Proliferation
Female
Glucose - pharmacology
Insulin - pharmacology
Islets of Langerhans - cytology
Male
Weaning
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Summary:Pancreatic beta cell proliferation is high at birth and then rapidly declines. In this issue of Developmental Cell, Stolovich-Rain et al. (2015) show that β cells’ capacity to increase proliferation in response to injury is unexpectedly not acquired until after weaning-related nutritional changes trigger a metabolic and regenerative competence program.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2015.02.016