SYNERAZOL, A NEW ANTIFUNGAL ANTIBIOTIC

Synerazol, a new antifungal antibiotic, was isolated from cultured broth of Aspergillus fumigatus SANK 10588. The structure was determined based on NMR and mass spectral evidences. Synerazol was found to be a related substance to pseurotin A. Synerazol was active against Candida albicans and other f...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1991/04/25, Vol.44(4), pp.382-389
Main Authors: ANDO, OSAMU, SATAKE, HITOMI, NAKAJIMA, MUTSUO, SATO, AKIRA, NAKAMURA, TAKEMICHI, KINOSHITA, TAKESHI, FURUYA, KOUHEI, HANEISHI, TATSUO
Format: Article
Language:English
Subjects:
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Applied microbiology
Aspergillus fumigatus
Aspergillus fumigatus - metabolism
Biological and medical sciences
Candida albicans
Candida albicans - drug effects
Chemical Phenomena
Chemistry, Physical
Clotrimazole - pharmacology
Drug Synergism
Fermentation
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbiology
Molecular Structure
Pyrrolidinones - chemistry
Pyrrolidinones - isolation & purification
Pyrrolidinones - pharmacology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Synerazol, a new antifungal antibiotic, was isolated from cultured broth of Aspergillus fumigatus SANK 10588. The structure was determined based on NMR and mass spectral evidences. Synerazol was found to be a related substance to pseurotin A. Synerazol was active against Candida albicans and other fungi, and showed marked synergistic activity with azole-type antifungal agents.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.44.382