Switch of CD8 T cells to noncytolytic CD8 super(-)CD4 super(-) cells that make T sub(H)2 cytokines and help B cells

CD8 super(+) T cells are a major defense against viral infections and intracellular parasites. Their production of interferon- gamma (IFN- gamma ) and their cytolytic activity are key elements in the immune response to these pathogens. Mature mouse CD8 super(+) T cells that were activated in the pre...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1993-01, Vol.260 (5115), p.1802-1805
Main Authors: Erard, F, Wild, M-T, Garcia-Sanz, JA, Le Gros, G
Format: Article
Language:English
Online Access:Get full text
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Summary:CD8 super(+) T cells are a major defense against viral infections and intracellular parasites. Their production of interferon- gamma (IFN- gamma ) and their cytolytic activity are key elements in the immune response to these pathogens. Mature mouse CD8 super(+) T cells that were activated in the presence of interleukin-4 (IL-4) developed into a CD8 super(-)CD4 super(-) population that was not cytolytic and did not produce IFN- gamma . However, these CD8 super(-) cells produced large amounts of IL-4, IL-5, and IL-10 and helped activate resting B cells. Thus, CD8 effector functions are potentially diverse and could be exploited by infectious agents that switch off host protective cytolytic responses.
ISSN:0036-8075